Valvular heart disease is a common cause of morbidity and mortality worldwide and has no
effective medical therapy. Severe disease is managed with valve replacement procedures …

Calcific aortic valve stenosis (CAS), the most prevalent valvular disease worldwide, has
been demonstrated to frequently occur in conjunction with coronary artery disease (CAD) …

Abstract Background and Aims Valve interstitial cells (VICs) undergo a transition to
intermediate state cells before ultimately transforming into the osteogenic cell population …

BACKGROUND: Fewer than 50% of patients who develop aortic valve calcification have
concomitant atherosclerosis, implying differential pathogenesis. Although circulating …

Hemodynamic overload and dysregulation of cellular metabolism are involved in
development of calcific aortic valve disease (CAVD). However, how mechanical stress …

Calcific aortic valve disease is a prevalent cardiovascular disease with no available drugs
capable of effectively preventing its progression. Hence, an efficient drug delivery system …

In calcific aortic valve disease (CAVD), mechanosensitive valvular cells respond to fibrosis-
and calcification-induced tissue stiffening, further driving pathophysiology. No …

The development of next‐generation biomimetic cardiovascular implants using tissue
engineering concepts can address the existing shortcomings of the clinically available …

The mineralization of the extracellular matrix (ECM) is an essential and crucial process for
physiological bone formation and pathological calcification. The abnormal function of ECM …

This review focuses on technologies at the core of calcific aortic valve disease (CAVD) and
drug target research advancement, including transcriptomics, proteomics, and molecular …