Epithelial cells display dynamic behaviours, such as rearrangement, movement and shape
changes, particularly during embryonic development and in equivalent processes in adults …

Rho-associated coiled-coil containing kinases (ROCK) were originally identified as effectors
of the RhoA small GTPase.–They belong to the AGC family of serine/threonine kinases and …

Apical constriction is a cell shape change that promotes tissue remodeling in a variety of
homeostatic and developmental contexts, including gastrulation in many organisms and …

Tight junctions (TJs) establish the epithelial barrier and are thought to form a membrane
fence to regulate epithelial polarity, although the roles of TJs in epithelial polarity remain …

Neurodegenerative disorders like Parkinson's disease, Alzheimer's disease, or amyotrophic
lateral sclerosis are affecting a rapidly increasing population worldwide. While common …

The structure and function of both adherens (AJ) and tight (TJ) junctions are dependent on
the cortical actin cytoskeleton. The zonula occludens (ZO)-1 and-2 proteins have context …

Circumferential actin belts underlying the adherens junctions of columnar epithelial cell
monolayers control intercellular surface tension and cell shape to maintain tissue integrity …

Morphogenesis requires dynamic coordination between cell–cell adhesion and the
cytoskeleton to allow cells to change shape and move without losing tissue integrity. We …

Abstract The small Rho GTPase family of proteins, encompassing the three major G-protein
classes Rho, Rac and cell division control protein 42, are key mitogenic signaling molecules …

Cdc42–a member of the small Rho GTPase family–regulates cell polarity across organisms
from yeast to humans. It is an essential regulator of polarized morphogenesis in epithelial …