Forty years ago the advent of Sanger sequencing was revolutionary as it allowed complete
genome sequences to be deciphered for the first time. A second revolution came when next …

Satellite DNA consists of abundant tandem repeats that play important roles in cellular
processes, including chromosome segregation, genome organization and chromosome end …

The completion of a telomere-to-telomere human reference genome, T2T-CHM13, has
resolved complex regions of the genome, including repetitive and homologous regions …

Abstract Motivation The Oxford Nanopore sequencing enables to directly detect methylation
states of bases in DNA from reads without extra laboratory techniques. Novel computational …

Centromeres are the specialized regions of the chromosomes that direct faithful
chromosome segregation during cell division. Despite their functional conservation …

Caenorhabditis elegans was the first multicellular eukaryotic genome sequenced to
apparent completion. Although this assembly employed a standard C. elegans strain (N2), it …

As is true of virtually every realm of the biological sciences, our understanding of speciation
is increasingly informed by the genomic revolution of the past decade. Investigators can ask …

In anamniote embryos, the major wave of zygotic genome activation starts during the mid-
blastula transition. However, some genes escape global genome repression, are activated …

Background African cichlid fishes are well known for their rapid radiations and are a model
system for studying evolutionary processes. Here we compare multiple, high-quality …

Heterochromatin marks such as H3K9me3 undergo global erasure and re-establishment
after fertilization, and the proper reprogramming of H3K9me3 is essential for early …