Mast cells in neuroinflammation and brain disorders

E Hendriksen, D van Bergeijk, RS Oosting… - Neuroscience & …, 2017 - Elsevier
It is well recognized that neuroinflammation is involved in the pathogenesis of various
neurodegenerative diseases. Microglia and astrocytes are major pathogenic components …

The role of mast cells in neuroinflammation

S Nelissen, E Lemmens, N Geurts, P Kramer… - Acta …, 2013 - Springer
Mast cells (MCs) are densely granulated perivascular resident cells of hematopoietic origin
and well known for their pathogenetic role in allergic and anaphylactic reactions. In addition …

Senescence-associated-β-galactosidase staining following traumatic brain injury in the mouse cerebrum

T Tominaga, R Shimada, Y Okada, T Kawamata… - PLoS …, 2019 - journals.plos.org
Primary and secondary traumatic brain injury (TBI) can cause tissue damage by inducing
cell death pathways including apoptosis, necroptosis, and autophagy. However, similar …

Gene expression in meningeal lymphatic endothelial cells following traumatic brain injury in mice

R Shimada, Y Tatara, K Kibayashi - PLoS One, 2022 - journals.plos.org
Meningeal lymphatic vessels transport both the cerebrospinal fluid and interstitial fluid to the
deep cervical lymph nodes. Traumatic brain injury (TBI) is accompanied by meningeal …

Responses of dural mast cells in concussive and blast models of mild traumatic brain injury in mice: Potential implications for post-traumatic headache

D Levy, S Edut, R Baraz-Goldstein, V Rubovitch… - …, 2016 - journals.sagepub.com
Background Chronic post-traumatic headache (PTH) is one of the most common symptoms
of mild traumatic brain injury (mTBI) but its underlying mechanisms remain unknown …

Traumatic brain injury decreases serotonin transporter expression in the rat cerebrum

K Abe, R Shimada, Y Okada, K Kibayashi - Neurological research, 2016 - Taylor & Francis
Objectives: An association has been postulated between traumatic brain injury (TBI) and
depression. The serotonin transporter (SERT) regulates the concentration of serotonin in the …

[HTML][HTML] Hypocretinergic and cholinergic contributions to sleep-wake disturbances in a mouse model of traumatic brain injury

HE Thomasy, HY Febinger, KM Ringgold… - Neurobiology of Sleep …, 2017 - Elsevier
Disorders of sleep and wakefulness occur in the majority of individuals who have
experienced traumatic brain injury (TBI), with increased sleep need and excessive daytime …

[HTML][HTML] Fatal traffic accidents and forensic medicine

K Kibayashi, R Shimada, K Nakao - IATSS research, 2014 - Elsevier
In the event of a traffic accident fatality, the death is reported as an “unusual death,” an
inquest is conducted, and, if necessary, a forensic autopsy is performed to prove any causal …

Changes in dopamine transporter expression in the midbrain following traumatic brain injury: an immunohistochemical and in situ hybridization study in a mouse …

R Shimada, K Abe, R Furutani… - Neurological …, 2014 - Taylor & Francis
Objectives: An association has been suggested between trauma and neurological
degenerative diseases. Magnetic resonance imaging has revealed that traumatic brain …

Contribution of mast cells to injury mechanisms in a mouse model of pediatric traumatic brain injury

R Moretti, V Chhor, D Bettati, E Banino… - Journal of …, 2016 - Wiley Online Library
The cognitive and behavioral deficits caused by traumatic brain injury (TBI) to the immature
brain are more severe and persistent than injuries to the adult brain. Understanding this …