Ubiquitous yet unique, lipid droplets are intracellular organelles that are increasingly being
recognized for their versatility beyond energy storage. Advances uncovering the intricacies …

Lipid droplets are dynamic organelles that store neutral lipids, serve the metabolic needs of
cells, and sequester lipids to prevent lipotoxicity and membrane damage. Here we review …

Cellular cholesterol can be metabolized to its fatty acid esters, cholesteryl esters (CEs), to be
stored in lipid droplets (LDs). With triacylglycerols (TGs), CEs represent the main neutral …

More than 60 years ago, Eugene Kennedy and coworkers elucidated the endoplasmic
reticulum (ER)-based pathways of glycerolipid synthesis, including the synthesis of …

Microbial cell factories for terpenoid synthesis form a less expensive and more environment-
friendly approach than chemical synthesis and extraction, and are thus being regarded as …

Membrane-bound organelles allow cells to traffic cargo and separate and regulate
metabolic pathways. While many organelles are generated by the growth and division of …

Lipid droplets (LDs) form in the endoplasmic reticulum by phase separation of neutral lipids.
This process is facilitated by the seipin protein complex, which consists of a ring of seipin …

Nonalcoholic steatohepatitis (NASH) increases with fructose consumption and metabolic
syndrome and has been recently linked with endogenous ethanol production, notably by …

In the last decade, molecular dynamics (MD) simulations have become an essential tool to
investigate the molecular properties of membrane trafficking processes, often in conjunction …

Lipid droplets (LDs) are essential for cellular lipid homeostasis by storing diverse neutral
lipids (NLs), such as triacylglycerol (TAG), steryl esters (SE), and retinyl esters (RE). A …