Genomic Characterization of Carbapenem-Non-susceptible Pseudomonas aeruginosa Clinical Isolates From Saudi Arabia Revealed a Global Dissemination of GES …

M Doumith, S Alhassinah, A Alswaji, M Alzayer… - Frontiers in …, 2022 - frontiersin.org
Carbapenem-resistant P. aeruginosa has become a major clinical problem due to limited
treatment options. However, studies assessing the trends in the molecular epidemiology and …

Aerobic Vitamin B12 Biosynthesis Is Essential for Pseudomonas aeruginosa Class II Ribonucleotide Reductase Activity During Planktonic and Biofilm Growth

A Crespo, N Blanco-Cabra, E Torrents - Frontiers in microbiology, 2018 - frontiersin.org
Pseudomonas aeruginosa is a major pathogenic bacterium in chronic infections and is a
model organism for studying biofilms. P. aeruginosa is considered an aerobic bacterium, but …

Gradual adaptation of facultative anaerobic pathogens to microaerobic and anaerobic conditions

L Pedraz, N Blanco‐Cabra, E Torrents - The FASEB Journal, 2020 - Wiley Online Library
Many notable human pathogens are facultative anaerobes. These pathogens exhibit
redundant metabolic pathways and a whole array of regulatory systems to adapt to changing …

Pseudomonas aeruginosa Exhibits Deficient Biofilm Formation in the Absence of Class II and III Ribonucleotide Reductases Due to Hindered Anaerobic Growth

A Crespo, L Pedraz, J Astola, E Torrents - Frontiers in microbiology, 2016 - frontiersin.org
Chronic lung infections by the ubiquitous and extremely adaptable opportunistic pathogen
Pseudomonas aeruginosa correlate with the formation of a biofilm, where bacteria grow in …

A nucleotide-sensing oligomerization mechanism that controls NrdR-dependent transcription of ribonucleotide reductases

I Rozman Grinberg, M Martínez-Carranza… - Nature …, 2022 - nature.com
Ribonucleotide reductase (RNR) is an essential enzyme that catalyzes the synthesis of DNA
building blocks in virtually all living cells. NrdR, an RNR-specific repressor, controls the …

Spotlight on alternative frame coding: Two long overlapping genes in Pseudomonas aeruginosa are translated and under purifying selection

M Kreitmeier, Z Ardern, M Abele, C Ludwig, S Scherer… - Iscience, 2022 - cell.com
The existence of overlapping genes (OLGs) with significant coding overlaps revolutionizes
our understanding of genomic complexity. We report two exceptionally long (957 nt and …

Comparative genomics and evolution of transcriptional regulons in Proteobacteria

SA Leyn, IA Suvorova, AE Kazakov… - Microbial …, 2016 - microbiologyresearch.org
Comparative genomics approaches are broadly used for analysis of transcriptional
regulation in bacterial genomes. In this work, we identified binding sites and reconstructed …

Pooled CRISPR Interference Screening Identifies Crucial Transcription Factors in Gas-Fermenting Clostridium ljungdahlii

H Zhang, H Feng, XH Xing, W Jiang… - ACS Synthetic …, 2024 - ACS Publications
Gas-fermenting Clostridium species hold tremendous promise for one-carbon
biomanufacturing. To unlock their full potential, it is crucial to unravel and optimize the …

Quantitative Proteomic Analysis of Staphylococcus aureus Treated With Punicalagin, a Natural Antibiotic From Pomegranate That Disrupts Iron Homeostasis and …

B Cooper, N Islam, Y Xu, HS Beard, WM Garrett… - …, 2018 - Wiley Online Library
Staphylococcus aureus, a bacterial, food‐borne pathogen of humans, can contaminate raw
fruits and vegetables. While physical and chemical methods are available to control S …

The global population stru cture of Lacticaseibacillus rhamnosus and its application to an investigation of a rare case of infective endocarditis

PP Santoiemma, SE Cohn, SWM Gatesy, AR Hauser… - Plos one, 2024 - journals.plos.org
Background Lacticaseibacillus (formerly Lactobacillus) rhamnosus is widely used in
probiotics or food supplements to promote microbiome health and may also be part of the …