Bone tumors, including primary bone tumors and bone metastases, have been plagued by
poor prognosis for decades. Although most tumor tissue is removed, clinicians are still …

OBJECTIVE: To evaluate the influence of pain on quality of life in breast cancer patients.
METHODS: A cross-sectional study of 400 patients, including 118 without metastasis, 160 …

Bone metastasis is a prominent cause of morbidity and mortality in cancer. High rates of
bone colonization in breast cancer, especially in the subtype expressing estrogen receptors …

Purpose Bone metastasis is observed in up to 70% of breast cancer patients. The currently
available treatment options are palliative in nature. Chemokine receptor 5 (CCR5) has …

Breast cancer (BC) represents the most incident cancer case in women (29%), with high
mortality rate. Bone metastasis occurs in 20–50% cases and, despite advances in BC …

The development of novel therapies for breast cancer bone metastasis is a major unmet
medical need. Toward that end, we have constructed an oncolytic adenovirus, Ad. dcn, and …

Advanced breast cancer is frequently associated with skeletal metastases and accelerated
bone loss. Recombinant parathyroid hormone [teriparatide, PTH (1-34)] is the first anabolic …

Bone metastases occur in 65% to 75% of patients with advanced breast cancer and
significantly worsen their survival and quality of life. We previously showed that conditioned …

Purpose To test the hypotheses that pathological biomarkers including CD34 positive
endothelial cell and microvessel density (MVD) of the primary breast tumor can be used to …

The majority of advanced breast cancer patients develop distal metastasis, including lung
and bone metastasis. However, effective therapeutic strategies to prevent metastasis are still …