[PDF][PDF] Protective alleles and precision healthcare in crewed spaceflight

LA Rutter, MJ MacKay, H Cope, NJ Szewczyk… - Nature …, 2024 - nature.com
Common and rare alleles are now being annotated across millions of human genomes, and
omics technologies are increasingly being used to develop health and treatment …

A systematic framework for understanding the microbiome in human health and disease: from basic principles to clinical translation

Z Ma, T Zuo, N Frey, AY Rangrez - Signal Transduction and Targeted …, 2024 - nature.com
The human microbiome is a complex and dynamic system that plays important roles in
human health and disease. However, there remain limitations and theoretical gaps in our …

The Space Omics and Medical Atlas (SOMA) and international astronaut biobank

EG Overbey, JK Kim, BT Tierney, J Park, N Houerbi… - Nature, 2024 - nature.com
Spaceflight induces molecular, cellular and physiological shifts in astronauts and poses
myriad biomedical challenges to the human body, which are becoming increasingly relevant …

Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight

JK Kim, BT Tierney, EG Overbey, E Dantas… - Nature …, 2024 - nature.com
Spaceflight induces an immune response in astronauts. To better characterize this effect, we
generated single-cell, multi-ome, cell-free RNA (cfRNA), biochemical, and hematology data …

Collection of biospecimens from the inspiration4 mission establishes the standards for the space omics and medical atlas (SOMA)

EG Overbey, K Ryon, JK Kim, BT Tierney… - Nature …, 2024 - nature.com
Abstract The SpaceX Inspiration4 mission provided a unique opportunity to study the impact
of spaceflight on the human body. Biospecimen samples were collected from four crew …

Direct RNA sequencing of astronaut blood reveals spaceflight-associated m6A increases and hematopoietic transcriptional responses

K Grigorev, TM Nelson, EG Overbey, N Houerbi… - Nature …, 2024 - nature.com
The advent of civilian spaceflight challenges scientists to precisely describe the effects of
spaceflight on human physiology, particularly at the molecular and cellular level. Newer …

Towards geospatially-resolved public-health surveillance via wastewater sequencing

BT Tierney, J Foox, KA Ryon, D Butler, N Damle… - Nature …, 2024 - nature.com
Wastewater is a geospatially-and temporally-linked microbial fingerprint of a given
population, making it a potentially valuable tool for tracking public health across locales and …

Beyond bacteria: Phanta adds flavour to microbiome profiling with a focus on phages

Y Pinto - Nature Reviews Immunology, 2025 - nature.com
Beyond bacteria: Phanta adds flavour to microbiome profiling with a focus on phages | Nature
Reviews Immunology Skip to main content Thank you for visiting nature.com. You are using a …

Thymus ad astra, or spaceflight-induced thymic involution

W Muramatsu, M Maryanovich, T Akiyama… - Frontiers in …, 2025 - frontiersin.org
Spaceflight imposes a constellation of physiological challenges—cosmic radiation,
microgravity, disrupted circadian rhythms, and psychosocial stress—that critically …

Review insights into the field of space life sciences

L Cheng, Y Li, J Yan - Life Sciences in Space Research, 2024 - Elsevier
Abstract Space life science has been a frontier discipline in the life sciences, aiming to study
the life phenomena of earth organisms and their activity patterns under the special …