Role of oxidative stress in the pathogenesis of non-alcoholic fatty liver disease: Implications for prevention and therapy

JC Arroyave-Ospina, Z Wu, Y Geng, H Moshage - Antioxidants, 2021 - mdpi.com
Oxidative stress (OxS) is considered a major factor in the pathophysiology of inflammatory
chronic liver diseases, including non-alcoholic liver disease (NAFLD). Chronic impairment of …

Nrf2: a dark horse in Alzheimer's disease treatment

A Osama, J Zhang, J Yao, X Yao, J Fang - Ageing research reviews, 2020 - Elsevier
Abstract Alzheimer's disease (AD), an age-dependent neurodegenerative disorder, is the
main cause of dementia. Common hallmarks of AD include the amyloid β-peptide (Aβ) …

Hesperetin ameliorates hepatic oxidative stress and inflammation via the PI3K/AKT-Nrf2-ARE pathway in oleic acid-induced HepG2 cells and a rat model of high-fat …

J Li, T Wang, P Liu, F Yang, X Wang, W Zheng… - Food & function, 2021 - pubs.rsc.org
Non-alcoholic fatty liver disease (NAFLD) is considered the most common liver disease.
Dietary supplementation has become a promising strategy for managing NAFLD …

Hesperetin, a citrus flavonoid, attenuates LPS-induced neuroinflammation, apoptosis and memory impairments by modulating TLR4/NF-κB signaling

T Muhammad, M Ikram, R Ullah, SU Rehman, MO Kim - Nutrients, 2019 - mdpi.com
Glial activation and neuroinflammation play significant roles in apoptosis as well as in the
development of cognitive and memory deficits. Neuroinflammation is also a critical feature in …

Antioxidant and Anti-Inflammatory Effects of Citrus Flavonoid Hesperetin: Special Focus on Neurological Disorders

A Khan, M Ikram, JR Hahm, MO Kim - Antioxidants, 2020 - mdpi.com
Neurodegenerative disorders have emerged as a serious health issue in the current era.
The most common neurodegenerative disorders are Alzheimer's disease (AD), Parkinson's …

Beneficial effects of natural flavonoids on neuroinflammation

Y Chen, F Peng, Z Xing, J Chen, C Peng… - Frontiers in …, 2022 - frontiersin.org
Neuroinflammation is the fundamental immune response against multiple factors in the
central nervous system and is characterized by the production of inflammatory mediators …

Natural products as modulators of Nrf2 signaling pathway in neuroprotection

I Moratilla-Rivera, M Sánchez… - International Journal of …, 2023 - mdpi.com
Neurodegenerative diseases (NDs) affect the West due to the increase in life expectancy.
Nervous cells accumulate oxidative damage, which is one of the factors that triggers and …

Solid lipid nanoparticles as carriers of natural phenolic compounds

A Borges, V de Freitas, N Mateus, I Fernandes… - Antioxidants, 2020 - mdpi.com
Phenolic compounds are one of the most widespread classes of compounds in nature, with
several beneficial biological effects being associated with their anti-oxidant and anti …

Impact of HMGB1, RAGE, and TLR4 in Alzheimer's disease (AD): from risk factors to therapeutic targeting

YN Paudel, E Angelopoulou, C Piperi, I Othman… - Cells, 2020 - mdpi.com
Alzheimer's disease (AD) is a devastating neurodegenerative disorder and a leading cause
of dementia, with accumulation of amyloid-beta (Aβ) and neurofibrillary tangles (NFTs) as …

Mediterranean diet on sleep: a health alliance

E Scoditti, MR Tumolo, S Garbarino - Nutrients, 2022 - mdpi.com
The Mediterranean diet is a plant-based, antioxidant-rich, unsaturated fat dietary pattern that
has been consistently associated with lower rates of noncommunicable diseases and total …