The coordinated action of the enzymes in the L-lysine biosynthetic pathway and how to inhibit it for antibiotic targets

S Muduli, S Karmakar, S Mishra - Biochimica et Biophysica Acta (BBA) …, 2023 - Elsevier
Background Antimicrobial resistance is a global health issue that requires immediate
attention in terms of new antibiotics and new antibiotic targets. The l-lysine biosynthesis …

Computational Modelling, Functional Characterization and Molecular Docking to Lead Compounds of Bordetella pertussis Diaminopimelate Epimerase

S Singh, A Praveen, SM Khanna - Applied Biochemistry and Biotechnology, 2023 - Springer
Bordetella pertussis, the causative agent of whooping cough, is an opportunistic virulent
bacterial pathogen that is resistant to a wide range of antibiotics due to a variety of …

Spectroscopic, computational, cytotoxicity, and docking studies of 6‐bromobenzimidazole as anti‐breast cancer agent

VS Kunjumol, S Jeyavijayan… - Journal of Molecular …, 2024 - Wiley Online Library
Bromobenzimidazole (6BBZ) has been calculated in this study utilizing the 6‐311++ G (d, p)
basis set and the Becke‐3‐Lee‐Yang‐Parr density functional approaches. The basic …

Big Data to Expand the Antimicrobial Therapeutic Arsenal: De Novo Discovery and Drug Repurposing

A Tarín-Pelló, B Suay-García, A Falcó… - … of Information Science …, 2025 - igi-global.com
The current big data era has vast amounts of biomedical data that present great interest in
processes related to the search of new drugs. Due to the information available in open …

Exploring the significance of diaminopimelate epimerase as a drug target in multidrug resistant Enterococcus faecalis

J Chaudhary, N Singh, VK Srivastava, A Jyoti… - Vegetos, 2023 - Springer
Enterococcus faecalis (E. faecalis) is a Gram-positive multidrug-resistant bacterium that is
involved in almost 75% of all nosocomial infections. Most E. faecalis infections occur as a …

[PDF][PDF] Computational modelling, molecular docking, and molecular dynamics simulation studies of Enterococcus faecalis diaminopimelate epimerase

J Chaudhary, P Sharma, N Singh, VK Srivastava… - kronika.ac
Computational modelling, molecular docking, and molecular dynamics simulation studies of
Enterococcus faecalis diaminopimelate e Page 1 Computational modelling, molecular …