Hedgehog (Hh) is first described as a genetic mutation that has “spiked” phenotype in the
cuticles of Drosophila in later 1970s. Since then, Hh signaling has been implicated in …

Membrane proteins are encoded by approximately a quarter of human genes. Inter-chain
residue-residue contact information is important for structure prediction of membrane protein …

The Smoothened (Smo) receptor is a key transducer of the Hedgehog (Hh) signaling
pathway, which plays a critical role in tissue maintenance and repair. Recent studies have …

Oligomerization of membrane proteins in response to lipid binding has a critical role in many
cell-signalling pathways but is often difficult to define or predict. Here we report the …

Selective coupling of G protein (heterotrimeric guanine nucleotide–binding protein)–coupled
receptors (GPCRs) to specific Gα-protein subtypes is critical to transform extracellular …

Membrane proteins often form oligomeric complexes within the lipid bilayer, but factors
controlling their assembly are hard to predict and experimentally difficult to determine. An …

The growing number of studies on G protein-coupled receptors (GPCRs) family are a source
of noticeable improvement in our understanding of the functioning of these proteins. GPCRs …

Protein folding is a fundamental process of life with important implications throughout
biology. Indeed, tens of thousands of mutations have been associated with diseases, and …

Peripheral myelin protein (PMP22) is an integral membrane protein that traffics inefficiently
even in wild-type (WT) form, with only 20% of the WT protein reaching its final plasma …

The Bcl-2 protein family comprises both pro-and antiapoptotic members that control the
permeabilization of the mitochondrial outer membrane, a crucial step in the modulation of …