Immunotherapies have revolutionized the treatment paradigms of various types of cancers.
However, most of these immunomodulatory strategies focus on harnessing adaptive …

Natural killer (NK) cells play critical roles in host immunity against cancer. In response,
cancers develop mechanisms to escape NK cell attack or induce defective NK cells. Current …

Systematic evaluation of the impact of genetic variants is critical for the study and treatment
of human physiology and disease. While specific mutations can be introduced by genome …

The bone marrow microenvironment has a key role in regulating haematopoiesis, but its
molecular complexity and response to stress are incompletely understood. Here we map the …

Unlimited generation of chimeric antigen receptor (CAR) T cells from human-induced
pluripotent stem cells (iPSCs) is an attractive approach for" off-the-shelf" CAR T cell …

Human natural killer (NK) cells comprise≈ 15% of all circulating lymphocytes. Owing to their
early production of cytokines and chemokines, and ability to lyse target cells without prior …

Natural killer (NK) cells were discovered more than 30 years ago. NK cells are large
granular lymphocytes that belong to the innate immune system because unlike T or B …

The identification of distinct tissue-specific natural killer (NK) cell populations that apparently
mature from local precursor populations has brought new insight into the diversity and …

During the innate immune response to infection, monocyte-derived cytokines (monokines),
stimulate natural killer (NK) cells to produce immunoregulatory cytokines that are important …

Adoptive transfer of antitumor lymphocytes has gained intense interest in the field of cancer
therapeutics over the past two decades. Human natural killer (NK) cells are a promising …