The pentose phosphate pathway in health and disease

T TeSlaa, M Ralser, J Fan, JD Rabinowitz - Nature metabolism, 2023 - nature.com
The pentose phosphate pathway (PPP) is a glucose-oxidizing pathway that runs in parallel
to upper glycolysis to produce ribose 5-phosphate and nicotinamide adenine dinucleotide …

Glucose-6-phosphate dehydrogenase: update and analysis of new mutations around the world

S Gómez-Manzo, J Marcial-Quino… - International journal of …, 2016 - mdpi.com
Glucose-6-phosphate dehydrogenase (G6PD) is a key regulatory enzyme in the pentose
phosphate pathway which produces nicotinamide adenine dinucleotide phosphate …

Use of primaquine and glucose-6-phosphate dehydrogenase deficiency testing: divergent policies and practices in malaria endemic countries

J Recht, EA Ashley, NJ White - PLoS neglected tropical diseases, 2018 - journals.plos.org
Primaquine is the only available antimalarial drug that kills dormant liver stages of
Plasmodium vivax and Plasmodium ovale malarias and therefore prevents their relapse …

Glucose-6-Phosphate dehydrogenase deficiency and neonatal hyperbilirubinemia: Insights on pathophysiology, diagnosis, and gene variants in disease …

HY Lee, A Ithnin, RZ Azma, A Othman… - Frontiers in …, 2022 - frontiersin.org
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a prevalent condition worldwide
and is caused by loss-of-function mutations in the G6PD gene. Individuals with deficiency …

Long-range structural defects by pathogenic mutations in most severe glucose-6-phosphate dehydrogenase deficiency

N Horikoshi, S Hwang, C Gati… - Proceedings of the …, 2021 - National Acad Sciences
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common blood
disorder, presenting multiple symptoms, including hemolytic anemia. It affects 400 million …

Laccase Production from Agrocybe pediades: Purification and Functional Characterization of a Consistent Laccase Isoenzyme in Liquid Culture

P González-González, S Gómez-Manzo, A Tomasini… - Microorganisms, 2023 - mdpi.com
Laccases are valuable enzymes as an excellent ecological alternative for bioremediation
issues because they can oxidize persistent xenobiotic compounds. The production and …

Glucose-6-phosphate dehydrogenase deficiency and the need for a novel treatment to prevent kernicterus

AD Cunningham, S Hwang… - Clinics in …, 2016 - perinatology.theclinics.com
Approximately 80% of newborns worldwide have some degree of hyperbilirubinemia and
visible jaundice. 1 Severe cases of hyperbilirubinemia can progress to kernicterus and lead …

The challenges of introducing routine G6PD testing into radical cure: a workshop report

B Ley, N Luter, FE Espino, A Devine, M Kalnoky… - 2015 - Springer
The only currently available drug that effectively removes malaria hypnozoites from the
human host is primaquine. The use of 8-aminoquinolines is hampered by haemolytic side …

An overall view of the functional and structural characterization of glucose-6-phosphate dehydrogenase variants in the Mexican population

B Hernández-Ochoa, D Ortega-Cuellar… - International Journal of …, 2023 - mdpi.com
Glucose-6-phosphate dehydrogenase (G6PD) deficiency, affecting an estimated 500 million
people worldwide, is a genetic disorder that causes human enzymopathies. Biochemical …

G6PDH as a key immunometabolic and redox trigger in arthropods

B Moraes, R Martins, C Lopes, R Martins… - Frontiers in …, 2023 - frontiersin.org
The enzyme glucose-6-phosphate dehydrogenase (G6PDH) plays crucial roles in glucose
homeostasis and the pentose phosphate pathway (PPP), being also involved in redox …