Aim The aim of this review is to inform the reader on the latest developments in
epidemiology, diagnostics and management. Epidemiology Drug-resistant Tuberculosis (DR …

Background Targeted next-generation sequencing (NGS) can rapidly and simultaneously
detect mutations associated with resistance to tuberculosis drugs across multiple gene …

With> 1 million associated deaths in 2020, human tuberculosis (TB) caused by the bacteria
Mycobacterium tuberculosis remains one of the deadliest infectious diseases. A plethora of …

Mycobacterium tuberculosis complex (MTBC) infections are treated with combinations of
antibiotics; however, these regimens are not as efficacious against multidrug and …

Background To determine the diagnostic accuracy of a nanopore sequencing assay of PCR
products from a M. tuberculosis complex-specific region for testing of bronchoalveolar …

Foodborne pathogens have become the subject of intense interest because of their high
incidence and mortality worldwide. In the past few decades, people have developed many …

Infectious diseases and tumors have become the biggest medical challenges in the 21st
century. They are driven by multiple factors such as population growth, aging, climate …

Recent, outbreaks of new emergency zoonotic diseases have prompted an urgent need to
develop fast, accurate, and portable screening assays for pathogen infections …

Drug-resistant tuberculosis (DR-TB) is still a major public health concern in South Africa.
Mutations in M. tuberculosis can cause varying levels of phenotypic resistance to anti-TB …

The current study aims to investigate the value of combination of NGS with Xpert MTB/RIF in
the diagnosis of early pulmonary tuberculosis (PTB). A total of 85 patients with suspected …