Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals
Individuals of admixed ancestries (for example, African Americans) inherit a mosaic of
ancestry segments (local ancestry) originating from multiple continental ancestral …
ancestry segments (local ancestry) originating from multiple continental ancestral …
[HTML][HTML] Viral-host dependency factors as therapeutic targets to overcome antiviral drug-resistance: a focus on innate immune modulation
The development of antiviral drugs, has provided enormous achievements in our recent
history in the fight against viral infections. To date, most of the approved antiviral drugs target …
history in the fight against viral infections. To date, most of the approved antiviral drugs target …
The lingering effects of Neanderthal introgression on human complex traits
The genetic variants introduced into the ancestors of modern humans from interbreeding
with Neanderthals have been suggested to contribute an unexpected extent to complex …
with Neanderthals have been suggested to contribute an unexpected extent to complex …
Human height: a model common complex trait
M Conery, SFA Grant - Annals of human biology, 2023 - Taylor & Francis
Context Like other complex phenotypes, human height reflects a combination of
environmental and genetic factors, but is notable for being exceptionally easy to measure …
environmental and genetic factors, but is notable for being exceptionally easy to measure …
Evaluating brain structure traits as endophenotypes using polygenicity and discoverability
Human brain structure traits have been hypothesized to be broad endophenotypes for
neuropsychiatric disorders, implying that brain structure traits are comparatively “closer to …
neuropsychiatric disorders, implying that brain structure traits are comparatively “closer to …
Causal effects on complex traits are similar across segments of different continental ancestries within admixed individuals
Individuals of admixed ancestries (eg, African Americans) inherit a mosaic of ancestry
segments (local ancestry) originating from multiple continental ancestral populations. Their …
segments (local ancestry) originating from multiple continental ancestral populations. Their …
Inferring disease architecture and predictive ability with LDpred2-auto
LDpred2 is a widely used Bayesian method for building polygenic scores (PGSs). LDpred2-
auto can infer the two parameters from the LDpred model, the SNP heritability h 2 and …
auto can infer the two parameters from the LDpred model, the SNP heritability h 2 and …
Heritability of complex traits in sub-populations experiencing bottlenecks and growth
CS Taylor, DJ Lawson - Journal of Human Genetics, 2024 - nature.com
Populations that have experienced a bottleneck are regularly used in Genome Wide
Association Studies (GWAS) to investigate variants associated with complex traits. It is …
Association Studies (GWAS) to investigate variants associated with complex traits. It is …
Characterizing the polygenic architecture of complex traits in populations of East Asian and European descent
To investigate the polygenicity of complex traits in populations of East Asian (EAS) and
European (EUR) descents, we leveraged genome-wide data from Biobank Japan, UK …
European (EUR) descents, we leveraged genome-wide data from Biobank Japan, UK …
A Bayesian method for estimating gene‐level polygenicity under the framework of transcriptome‐wide association study
A Majumdar, B Pasaniuc - Statistics in Medicine, 2023 - Wiley Online Library
Polygenicity refers to the phenomenon that multiple genetic variants have a nonzero effect
on a complex trait. It is defined as the proportion of genetic variants with a nonzero effect on …
on a complex trait. It is defined as the proportion of genetic variants with a nonzero effect on …