Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …

Few cell signals match the impact of the transforming growth factor-β (TGFβ) family in
metazoan biology. TGFβ cytokines regulate cell fate decisions during development, tissue …

Smad transcription factors activated by TGF-β or by BMP receptors form trimeric complexes
with Smad4 to target specific genes for cell fate regulation. The CAGAC motif has been …

Following a chronic insult, renal tubular epithelial cells (TECs) contribute to the development
of kidney fibrosis through dysregulated lipid metabolism that lead to lipid accumulation and …

Human embryonic stem cells (hESCs) possess the potential of long-term self-renewal and
three primary germ layers differentiation, and thus hESCs are expected to have broad …

Corticogenesis consists of a series of synchronised events, including fate transition of
cortical progenitors, neuronal migration, specification and connectivity. NeuroD1, a basic …

Dynamic epigenomic reprogramming occurs during mammalian oocyte maturation and early
development. However, the underlying transcription circuitry remains poorly characterized …

Muscle stem cells (MuSCs) are essential for skeletal muscle development and regeneration,
ensuring muscle integrity and normal function. The myogenic proliferation and differentiation …

Directed differentiation of mouse embryonic stem cells (mESCs) or induced pluripotent stem
cells (iPSCs) provides powerful models to dissect the molecular mechanisms leading to the …

Induced pluripotent stem cells (iPSCs) are generated by direct reprogramming of somatic
cells and hold great promise for novel therapies. However, several studies have reported …