The RNA exosome complex is the most versatile RNA-degradation machine in eukaryotes.
The exosome has a central role in several aspects of RNA biogenesis, including RNA …

Since determination of the myoglobin structure in 1957, X-ray crystallography, as the
anchoring tool of structural biology, has played an instrumental role in deciphering the …

From the earliest comparisons of RNA production with steady-state levels, it has been clear
that cells transcribe more RNA than they accumulate, implying the existence of active RNA …

Nucleases cleave the phosphodiester bonds of nucleic acids and may be endo or exo,
DNase or RNase, topoisomerases, recombinases, ribozymes, or RNA splicing enzymes. In …

Many RNA-binding proteins have modular structures and are composed of multiple repeats
of just a few basic domains that are arranged in various ways to satisfy their diverse …

When considering the control of gene expression, the focus has traditionally been on
transcriptional regulation. Recently, however, the large contribution made by mRNA decay …

We have ablated the cellular RNA degradation machinery in differentiated B cells and
pluripotent embryonic stem cells (ESCs) by conditional mutagenesis of core (Exosc3) and …

The eukaryotic RNA exosome is an essential and conserved protein complex that can
degrade or process RNA substrates in the 3′-to-5′ direction. Since its discovery nearly …

All RNA species in yeast cells are subject to turnover. Work over the past 20 years has
defined degradation mechanisms for messenger RNAs, transfer RNAs, ribosomal RNAs …

A well-defined mechanism governs the maturation of most microRNAs (miRNAs) in animals,
via stepwise cleavage of precursor hairpin transcripts by the Drosha and Dicer RNase III …