Biomarkers predicting clinical outcome of epidermal growth factor receptor–targeted therapy in metastatic colorectal cancer

S Siena, A Sartore-Bianchi… - Journal of the …, 2009 - academic.oup.com
The monoclonal antibodies panitumumab and cetuximab that target the epidermal growth
factor receptor (EGFR) have expanded the range of treatment options for metastatic …

[PDF][PDF] Magnesium and cancer: a dangerous liason

S Castiglioni, JAM Maier - Magnesium research, 2011 - mgwater.com
A complex relationship links magnesium and cancer. The aim of this review is to revisit
current knowledge concerning the contribution of magnesium to tumorigenesis, from …

Nephrotoxicity of recent anti-cancer agents

N Lameire - Clinical kidney journal, 2014 - academic.oup.com
Cancer patients may develop a variety of kidney lesions that impair not only their immediate
survival but also limit the adequate treatment of the underlying malignant process. This …

Electrolyte disorders associated with the use of anticancer drugs

G Liamis, TD Filippatos, MS Elisaf - European journal of pharmacology, 2016 - Elsevier
The use of anticancer drugs is beneficial for patients with malignancies but is frequently
associated with the occurrence of electrolyte disorders, which can be hazardous and in …

Epidermal growth factor receptor: pathway, therapies, and pipeline

JR Goffin, K Zbuk - Clinical therapeutics, 2013 - Elsevier
Background The epidermal growth factor receptor (EGFR) pathway is important in tumor
growth, survival, and metastasis and is now the target of several therapeutic agents …

Prognostic and predictive biomarkers for epidermal growth factor receptor-targeted therapy in colorectal cancer: beyond KRAS mutations

A Custodio, J Feliu - Critical reviews in oncology/hematology, 2013 - Elsevier
The advent of the epidermal growth factor receptor (EGFR)-targeted monoclonal antibodies
(mAbs), cetuximab and panitumumab has expanded the range of treatment options for …

Dual targeting of the epidermal growth factor receptor using the combination of cetuximab and erlotinib: preclinical evaluation and results of the phase II DUX study in …

AJ Weickhardt, TJ Price, G Chong, V Gebski… - Journal of clinical …, 2012 - ascopubs.org
Purpose This preclinical and phase II study evaluated the efficacy and safety of the
combination of cetuximab and erlotinib in metastatic colorectal cancer (mCRC). Patients and …

Risk of anti-EGFR monoclonal antibody-related hypomagnesemia: systematic review and pooled analysis of randomized studies

F Petrelli, K Borgonovo, M Cabiddu… - Expert Opinion on …, 2012 - Taylor & Francis
Introduction: The typical class side effect of anti-epidermal growth factor receptor (EGFR)
monoclonal antibodies (panitumumab and cetuximab) is a cutaneous maculopapular rash …

Identification of novel off targets of baricitinib and tofacitinib by machine learning with a focus on thrombosis and viral infection

ML Faquetti, F Grisoni, P Schneider, G Schneider… - Scientific reports, 2022 - nature.com
As there are no clear on-target mechanisms that explain the increased risk for thrombosis
and viral infection or reactivation associated with JAK inhibitors, the observed elevated risk …

Magnesium and tumors: ally or foe?

FI Wolf, ARM Cittadini, JAM Maier - Cancer treatment reviews, 2009 - Elsevier
Magnesium plays a crucial role in many cell functions such as energy metabolism, protein
and DNA syntheses, and cytoskeleton activation. Proliferating cells have long been known …