Optogenetic techniques have been developed to allow control over the activity of selected
cells within a highly heterogeneous tissue, using a combination of genetic engineering and …

The electromechanical function of the heart involves complex, coordinated activity over time
and space. Life-threatening cardiac arrhythmias arise from asynchrony in these space–time …

Small animals support a wide range of pathological phenotypes and genotypes as versatile,
affordable models for pathogenesis of cardiovascular diseases and for exploration of …

Designing bioelectronic devices that seamlessly integrate with the human body is a
technological pursuit of great importance. Bioelectronic medical devices that reliably and …

The motions of the heart are regulated by electrophysiological signals, which can be
monitored and altered by bioelectronic devices for the diagnosis and treatment of …

We aim to provide a critical appraisal of basic concepts underlying signal recording and
processing technologies applied for (i) atrial fibrillation (AF) mapping to unravel AF …

Optogenetics is an elegant approach of precisely controlling and monitoring the biological
functions of a cell, group of cells, tissues, or organs with high temporal and spatial resolution …

The development of new approaches to control cardiac arrhythmias requires a deep
understanding of spiral wave dynamics. Optogenetics offers new possibilities for this …

Genetic engineering and implantable bioelectronics have transformed investigations of
cardiovascular physiology and disease. However, the two approaches have been difficult to …

Optogenetic defibrillation of hearts expressing light-sensitive cation channels (eg, ChR2)
has been proposed as an alternative to conventional electrotherapy. Past modeling work …