With the recent explosion of chemical libraries beyond a billion molecules, more efficient
virtual screening approaches are needed. The Deep Docking (DD) platform enables up to …

Simple Summary Breast cancer is one of the leading causes of death among women
worldwide. Breast cancer may be provoked due to several physical, chemical and …

With the introduction of the European Commission's “Safe and Sustainable-by-
Design”(SSbD) framework, the interest in understanding the implications of safety and …

G9a is a histone-lysine methyltransferase that performs the mono-and dimethylation of
lysine 9 at histone 3 of the nucleosome. It belongs to the SET PKMT family, and its …

Pharmaceutical drug analysis (PDA), besides quantifying drugs and related substances
(RS), can enrich drug discovery (DD) by suggesting new leads. PDA may be extended …

Highlights•High throughput technologies (HTPs) provide quantitative and multi-dimensional
omics data.•Available HTPs can capture biological alterations in DNA, RNA, protein, and …

The structure-activity relationships data available in public databases of inhibitors of DNA
methyltransferases (DNMTs), families of epigenetic targets, plus the structural information of …

The importance of epigenetic drug and probe discovery is on the rise. This is not only
paramount to identify and develop therapeutic treatments associated with epigenetic …

Epigenetic targets are of significant importance in drug discovery research, as demonstrated
by the eight approved epigenetic drugs for treatment of cancer and the increasing …

Abstract Lysine demethylase 5 C (KDM5C) controls epigenetic gene expression and is
attracting great interest in the field of chemical epigenetics. KDM5C has emerged as a …