Metal‐catalyzed cross‐coupling reactions belong to the most important transformations in
organic synthesis. Copper catalysis has received great attention owing to the low toxicity …

Fluorine has emerged as a “magic element” in medicinal chemistry, crop, and materials
science. 1 Although fluorine is the most abundant halogen in the earth's crust, it is contained …

Fluorine, often called as “a small atom with a big ego”, 1 lies in the second row and the 17th
column in the periodic table of the chemical elements. This unique position in the periodic …

The trifluoromethyl (CF3) group is an essential moiety in medicinal chemistry due to its
unique physicochemical properties. While trifluoroacetic acid (TFA) is an inexpensive and …

The incorporation of a trifluoromethyl (CF3) group into organic compounds is of great
importance in pharmaceutical, agricultural, and materials science. Trifluoromethylation …

C–H functionalization chemistry is one of the most vibrant research areas within synthetic
organic chemistry. While most researchers focus on the development of small-scale batch …

An iridium/bipyridine‐catalyzed ortho‐selective C− H borylation of aryl sulfides was
developed. High ortho‐selectivity was achieved by a Lewis acid–base interaction between a …

The first example of the 3-position-selective C (sp2)–H trifluoromethylation of pyridine rings
was established. 3-Position-selective trifluoromethylation was achieved by the nucleophilic …

Abstract A photochemical [2+ 2] cycloaddition of alkynyl boronates and maleimides is
reported. The developed protocol provided 35–70% yield of maleimide‐derived …

Abstract Sodium trifluoromethanesulfinate, CF 3 SO 2 Na, and trifluoromethanesulfonyl
chloride, CF 3 SO 2 Cl, are two popular reagents that are widely used for the direct …