[HTML][HTML] Ubiquitination of phosphatidylethanolamine in organellar membranes
J Sakamaki, KL Ode, Y Kurikawa, HR Ueda… - Molecular cell, 2022 - cell.com
The covalent conjugation of ubiquitin family proteins is a widespread post-translational
protein modification. In the ubiquitin family, the ATG8 subfamily is exceptional because it is …
protein modification. In the ubiquitin family, the ATG8 subfamily is exceptional because it is …
A unifying model for the role of the ATG8 system in autophagy
The formation of autophagosomes and their fusion with lysosomes are key events that
underpin autophagic degradation of cargoes. The core ATG8 system, which consists of the …
underpin autophagic degradation of cargoes. The core ATG8 system, which consists of the …
AlphaFold2-multimer guided high-accuracy prediction of typical and atypical ATG8-binding motifs
Macroautophagy/autophagy is an intracellular degradation process central to cellular
homeostasis and defense against pathogens in eukaryotic cells. Regulation of autophagy …
homeostasis and defense against pathogens in eukaryotic cells. Regulation of autophagy …
Stress granules and mTOR are regulated by membrane atg8ylation during lysosomal damage
We report that lysosomal damage is a hitherto unknown inducer of stress granule (SG)
formation and that the process termed membrane atg8ylation coordinates SG formation with …
formation and that the process termed membrane atg8ylation coordinates SG formation with …
A guide to membrane atg8ylation and autophagy with reflections on immunity
The process of membrane atg8ylation, defined herein as the conjugation of the ATG8 family
of ubiquitin-like proteins to membrane lipids, is beginning to be appreciated in its broader …
of ubiquitin-like proteins to membrane lipids, is beginning to be appreciated in its broader …
Evolutionary diversification of the autophagy-related ubiquitin-like conjugation systems
S Zhang, E Yazaki, H Sakamoto, H Yamamoto… - Autophagy, 2022 - Taylor & Francis
Two autophagy-related (ATG) ubiquitin-like conjugation systems, the ATG12 and ATG8
systems, play important roles in macroautophagy. While multiple duplications and losses of …
systems, play important roles in macroautophagy. While multiple duplications and losses of …
TDP-43 regulates LC3ylation in neural tissue through ATG4B cryptic splicing inhibition
P Torres, S Rico-Rios, M Ceron-Codorniu… - Acta …, 2024 - Springer
Amyotrophic lateral sclerosis (ALS) is an adult-onset motor neuron disease with a mean
survival time of three years. The 97% of the cases have TDP-43 nuclear depletion and …
survival time of three years. The 97% of the cases have TDP-43 nuclear depletion and …
LC3B conjugation machinery promotes autophagy-independent HIV-1 entry in CD4+ T lymphocytes
B Pradel, G Cantaloube, M Villares, MS Deffieu… - Autophagy, 2024 - Taylor & Francis
ABSTRACT HIV-1 entry into CD4+ T lymphocytes relies on the viral and cellular membranes'
fusion, leading to viral capsid delivery in the target cell cytoplasm. Atg8/LC3B conjugation to …
fusion, leading to viral capsid delivery in the target cell cytoplasm. Atg8/LC3B conjugation to …
Atg8ylation as a host-protective mechanism against Mycobacterium tuberculosis
V Deretic - Frontiers in tuberculosis, 2023 - frontiersin.org
Nearly two decades have passed since the first report on autophagy acting as a cell-
autonomous defense against Mycobacterium tuberculosis. This helped usher a new area of …
autonomous defense against Mycobacterium tuberculosis. This helped usher a new area of …
To eat or not to eat: a critical review on the role of autophagy in prostate carcinogenesis and prostate cancer therapeutics
NJ Kurganovs, N Engedal - Frontiers in Pharmacology, 2024 - frontiersin.org
Around 1 in 7 men will be diagnosed with prostate cancer during their lifetime. Many strides
have been made in the understanding and treatment of this malignancy over the years …
have been made in the understanding and treatment of this malignancy over the years …