The nonstructural proteins directing coronavirus RNA synthesis and processing
Coronaviruses are animal and human pathogens that can cause lethal zoonotic infections
like SARS and MERS. They have polycistronic plus-stranded RNA genomes and belong to …
like SARS and MERS. They have polycistronic plus-stranded RNA genomes and belong to …
Nidovirales: evolving the largest RNA virus genome
AE Gorbalenya, L Enjuanes, J Ziebuhr, EJ Snijder - Virus research, 2006 - Elsevier
This review focuses on the monophyletic group of animal RNA viruses united in the order
Nidovirales. The order includes the distantly related coronaviruses, toroviruses, and …
Nidovirales. The order includes the distantly related coronaviruses, toroviruses, and …
Crystal structure of Nsp15 endoribonuclease NendoU from SARS‐CoV‐2
Y Kim, R Jedrzejczak, NI Maltseva… - Protein …, 2020 - Wiley Online Library
Abstract Severe Acute Respiratory Syndrome coronavirus 2 (SARS‐CoV‐2) is rapidly
spreading around the world. There is no existing vaccine or proven drug to prevent …
spreading around the world. There is no existing vaccine or proven drug to prevent …
Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2
Abstract SARS-CoV-2 Nsp15 is a uridine-specific endoribonuclease with C-terminal catalytic
domain belonging to the EndoU family that is highly conserved in coronaviruses. As …
domain belonging to the EndoU family that is highly conserved in coronaviruses. As …
Polymorphic toxin systems: comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative …
Background Proteinaceous toxins are observed across all levels of inter-organismal and
intra-genomic conflicts. These include recently discovered prokaryotic polymorphic toxin …
intra-genomic conflicts. These include recently discovered prokaryotic polymorphic toxin …
Comprehensive analysis of the HEPN superfamily: identification of novel roles in intra-genomic conflicts, defense, pathogenesis and RNA processing
Background The major role of enzymatic toxins that target nucleic acids in biological
conflicts at all levels has become increasingly apparent thanks in large part to the advances …
conflicts at all levels has become increasingly apparent thanks in large part to the advances …
Evolution of the deaminase fold and multiple origins of eukaryotic editing and mutagenic nucleic acid deaminases from bacterial toxin systems
The deaminase-like fold includes, in addition to nucleic acid/nucleotide deaminases, several
catalytic domains such as the JAB domain, and others involved in nucleotide and ADP …
catalytic domains such as the JAB domain, and others involved in nucleotide and ADP …
Structural basis of severe acute respiratory syndrome coronavirus ADP-ribose-1 ″-phosphate dephosphorylation by a conserved domain of nsP3
KS Saikatendu, JS Joseph, V Subramanian, T Clayton… - Structure, 2005 - cell.com
The crystal structure of a conserved domain of nonstructural protein 3 (nsP3) from severe
acute respiratory syndrome coronavirus (SARS-CoV) has been solved by single-wavelength …
acute respiratory syndrome coronavirus (SARS-CoV) has been solved by single-wavelength …
Structures of SARS-CoV-2 RNA-binding proteins and therapeutic targets
Background: The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) epidemic
has resulted in thousands of infections and deaths worldwide. Several therapies are …
has resulted in thousands of infections and deaths worldwide. Several therapies are …
Crystal structure and mechanistic determinants of SARS coronavirus nonstructural protein 15 define an endoribonuclease family
S Ricagno, MP Egloff, R Ulferts… - Proceedings of the …, 2006 - National Acad Sciences
The≈ 30-kb coronavirus (+) RNA genome is replicated and transcribed by a membrane-
bound replicase complex made up of 16 viral nonstructural proteins (nsp) with multiple …
bound replicase complex made up of 16 viral nonstructural proteins (nsp) with multiple …