The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is
crucial for transducing signals from a variety of metabolically relevant hormones and …

Patients with obesity have a high prevalence of nonalcoholic fatty liver disease (NAFLD),
representing a spectrum of simple steatosis to nonalcoholic steatohepatitis (NASH), without …

Elevated liver de novo lipogenesis contributes to non-alcoholic steatohepatitis (NASH) and
can be inhibited by targeting acetyl-CoA carboxylase (ACC). However, hypertriglyceridemia …

Adult growth hormone deficiency (GHD) is characterized by metabolic abnormalities
associated with visceral obesity, impaired quality of life, and increased mortality. Patients …

There is a wide variety of kinds of lipids, and complex structures which determine the
diversity and complexity of their functions. With the basic characteristic of water insolubility …

Precision medicine defines the attempt to identify the most effective approaches for specific
subsets of patients based on their genetic background, clinical features, and environmental …

Aging is associated with dysregulation of glucose and lipid metabolism. Various factors that
contribute to the dysregulation include both modifiable (eg obesity, insulin resistance) and …

Secondary nonalcoholic fatty liver disease (NAFLD) defines those complex
pathophysiological and clinical consequences that ensue when the liver becomes an …

Context Obesity is a state of relative growth hormone (GH) deficiency, and GH has been
identified as a candidate disease-modifying target in nonalcoholic fatty liver disease …

Growth hormone (GH) is a pleiotropic hormone that coordinates an array of physiological
processes, including effects on bone, muscle, and fat, ultimately resulting in growth …