Relaxin family peptides and their receptors

RAD Bathgate, ML Halls… - Physiological …, 2013 - journals.physiology.org
There are seven relaxin family peptides that are all structurally related to insulin. Relaxin has
many roles in female and male reproduction, as a neuropeptide in the central nervous …

Relaxin's physiological roles and other diverse actions

OD Sherwood - Endocrine reviews, 2004 - academic.oup.com
Relaxin has vital physiological roles in pregnant rats, mice, and pigs. Relaxin promotes
growth and softening of the cervix, thus facilitating rapid delivery of live young. Relaxin also …

[图书][B] Paxinos and Franklin's the Mouse brain in stereotaxic coordinates, compact: The coronal plates and diagrams

KBJ Franklin, G Paxinos - 2019 - books.google.com
Paxinos and Franklin's The Mouse Brain in Stereotaxic Coordinates, Compact Fifth Edition,
is the compact version of the most widely used and cited atlas of the mouse brain in print. It …

Are periaqueductal gray and dorsal raphe the foundation of appetitive and aversive control? A comprehensive review

C Silva, N McNaughton - Progress in neurobiology, 2019 - Elsevier
Many see the periaqueductal gray (PAG) as a region responsible for the downstream control
of defensive reactions. Here we provide a detailed review of anatomical and functional data …

Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein-coupled receptor GPCR135

C Liu, E Eriste, S Sutton, J Chen, B Roland… - Journal of Biological …, 2003 - ASBMB
GPCR135, publicly known as somatostatin-and angiotensin-like peptide receptor, is
expressed in the central nervous system and its cognate ligand (s) has not been identified …

Neurons expressing relaxin 3/INSL 7 in the nucleus incertus respond to stress

M Tanaka, N Iijima, Y Miyamoto… - European Journal of …, 2005 - Wiley Online Library
Relaxin 3/INSL 7 has recently been identified as a new member of the insulin/relaxin
superfamily. Although it was reported to be dominantly expressed in the brain, its detailed …

H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2

S Sudo, J Kumagai, S Nishi, S Layfield… - Journal of Biological …, 2003 - ASBMB
Leucine-rich repeat-containing, G protein-coupled receptors (LGRs) represent a unique
subgroup of G protein-coupled receptors with a large ectodomain. Recent studies …

Relaxin-3 in GABA projection neurons of nucleus incertus suggests widespread influence on forebrain circuits via G-protein-coupled receptor-135 in the rat

S Ma, P Bonaventure, T Ferraro, PJ Shen, TCD Burazin… - Neuroscience, 2007 - Elsevier
Relaxin-3 (RLX3) is a newly identified member of the relaxin/insulin peptide family that is
highly conserved across a range of species from fish to mammals and is highly expressed in …

International Union of Basic and Clinical Pharmacology. XCV. Recent advances in the understanding of the pharmacology and biological roles of relaxin family …

ML Halls, RAD Bathgate, SW Sutton… - Pharmacological …, 2015 - Elsevier
Abstract Relaxin, insulin-like peptide 3 (INSL3), relaxin-3, and INSL5 are the cognate
ligands for the relaxin family peptide (RXFP) receptors 1–4, respectively. RXFP1 activates …

Distribution of relaxin‐3 and RXFP3 within arousal, stress, affective, and cognitive circuits of mouse brain

CM Smith, PJ Shen, A Banerjee… - Journal of …, 2010 - Wiley Online Library
Abstract Relaxin‐3 (RLN3) and its native receptor, relaxin family peptide 3 receptor
(RXFP3), constitute a newly identified neuropeptide system enriched in mammalian brain …