The actin cytoskeleton—a collection of actin filaments with their accessory and regulatory
proteins—is the primary force-generating machinery in the cell. It can produce pushing …

The MYH9 gene encodes the heavy chain of non-muscle myosin IIA, a widely expressed
cytoplasmic myosin that participates in a variety of processes requiring the generation of …

The tight junction creates an intercellular barrier limiting paracellular movement of solutes
and material across epithelia. Currently many proteins have been identified as components …

Apical constriction is a cell shape change that promotes tissue remodeling in a variety of
homeostatic and developmental contexts, including gastrulation in many organisms and …

The cadherin-catenin adhesion complex is the key component of the intercellular adherens
junction (AJ) that contributes both to tissue stability and dynamic cell movements in epithelial …

Highly ordered organisation of striated muscle is the prerequisite for the fast and
unidirectional development of force and motion during heart and skeletal muscle …

Tight junctions (TJ) play a central role in the homeostasis of epithelial and endothelial
tissues, by providing a semipermeable barrier to ions and solutes, by contributing to the …

Although myosin II filaments are known to exist in non-muscle cells,, their dynamics and
organization are incompletely understood. Here, we combined structured illumination …

Cell adhesion systems are defined by their ability to resist detachment force. Our
understanding of the biology of cell–cell adhesions has recently been transformed by the …

Morphogenesis requires dynamic coordination between cell–cell adhesion and the
cytoskeleton to allow cells to change shape and move without losing tissue integrity. We …