[HTML][HTML] Updated diagnostic criteria and classification of mast cell disorders: a consensus proposal

P Valent, C Akin, K Hartmann, I Alvarez-Twose… - …, 2021 - journals.lww.com
Mastocytosis is a hematologic neoplasm characterized by expansion and focal
accumulation of neoplastic mast cells (MC) in diverse organs, including the skin, bone …

Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts

P Valent, C Akin, DD Metcalfe - Blood, The Journal of the …, 2017 - ashpublications.org
Over the past few years, substantial advances have been made in understanding the
pathogenesis, evolution, and complexity of mast cell neoplasms. New diagnostic and …

International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data

DA Arber, A Orazi, RP Hasserjian… - Blood, The Journal …, 2022 - ashpublications.org
The classification of myeloid neoplasms and acute leukemias was last updated in 2016
within a collaboration between the World Health Organization (WHO), the Society for …

Advances in the classification and treatment of mastocytosis: current status and outlook toward the future

P Valent, C Akin, K Hartmann, G Nilsson, A Reiter… - Cancer research, 2017 - AACR
Mastocytosis is a term used to denote a heterogeneous group of conditions defined by the
expansion and accumulation of clonal (neoplastic) tissue mast cells in various organs. The …

[HTML][HTML] Personalized management strategies in mast cell disorders: ECNM-AIM user's guide for daily clinical practice

P Valent, K Hartmann, J Schwaab… - The Journal of Allergy …, 2022 - Elsevier
Mastocytosis is a myeloid neoplasm defined by expansion and focal accumulation of clonal
mast cells (MCs) in one or more organs. The disease exhibits a complex pathology and may …

The international consensus classification of mastocytosis and related entities

RJ Leguit, SA Wang, TI George, A Tzankov, A Orazi - Virchows Archiv, 2023 - Springer
Mastocytosis is a neoplasm characterized by a clonal proliferation of mast cells, which
accumulate in one or multiple organs, associated with an extremely heterogeneous clinical …

Efficacy and safety of midostaurin in patients with advanced systemic mastocytosis: 10-year median follow-up of a phase II trial

DJ DeAngelo, TI George, A Linder, C Langford… - Leukemia, 2018 - nature.com
Patients with advanced systemic mastocytosis (SM)(eg aggressive SM (ASM), SM with an
associated hematologic neoplasm (SM-AHN) and mast cell leukemia (MCL)) have limited …

Mast cell leukemia: clinical and molecular features and survival outcomes of patients in the ECNM Registry

VE Kennedy, C Perkins, A Reiter, M Jawhar… - Blood …, 2023 - ashpublications.org
Mast cell leukemia (MCL) is a rare subtype of systemic mastocytosis defined by≥ 20% mast
cells (MC) on a bone marrow aspirate. We evaluated 92 patients with MCL from the …

Multidisciplinary challenges in mastocytosis and how to address with personalized medicine approaches

P Valent, C Akin, KV Gleixner, WR Sperr… - International journal of …, 2019 - mdpi.com
Mastocytosis is a hematopoietic neoplasm defined by abnormal expansion and focal
accumulation of clonal tissue mast cells in various organ-systems. The disease exhibits a …

The international consensus classification of eosinophilic disorders and systemic mastocytosis

SA Wang, A Orazi, J Gotlib, A Reiter… - American journal of …, 2023 - Wiley Online Library
Based on new data and increased understanding of disease molecular genetics, the
international consensus classification (ICC) has made several changes in the diagnosis and …