The specific regulation of inflammatory processes by steroid hormones has been actively
studied in recent years, especially by progesterone (P4) and progestins. The mechanisms of …

Cells respond to protein-damaging (proteotoxic) stress by activation of the Heat Shock
Response (HSR). The HSR provides cells with an enhanced ability to endure proteotoxic …

Hsp90 is an essential molecular chaperone responsible for the folding and activation of
hundreds of 'client'proteins, including the glucocorticoid receptor (GR). Previously, we …

Cancer stem cells (CSCs) are a great challenge in the fight against cancer because these
self-renewing tumorigenic cell fractions are thought to be responsible for metastasis …

FK506 binding (FKBP) proteins are part of the highly conserved immunophilin family and its
members have fundamental roles in the regulation of signalling pathways involved in …

Chronic activation and dysregulation of the neuroendocrine stress response have severe
physiological and psychological consequences, including the development of metabolic and …

The normal stress response in humans is governed by the hypothalamic-pituitary-adrenal
(HPA) axis through heightened mechanisms during stress, raising blood levels of the …

The Hsp90 chaperone promotes folding and activation of hundreds of client proteins in the
cell through an ATP-dependent conformational cycle guided by distinct cochaperone …

The molecular chaperone FK506-binding protein 51 (FKBP51) is gaining attention as a
meaningful biomarker of metabolic dysfunction. This review examines the emerging …

Hsp90 (Heat Shock Protein 90) is an ATP (Adenosine triphosphate) molecular chaperone
responsible for the activation and maturation of client proteins. The mechanism by which …