The arachidonic acid (AA) pathway plays a key role in cardiovascular biology,
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …

The vascular endothelium, a monolayer of endothelial cells (EC), constitutes the inner
cellular lining of arteries, veins and capillaries and therefore is in direct contact with the …

The cardiovascular effects of epoxyeicosatrienoic acids (EETs) include vasodilation,
antimigratory actions on vascular smooth muscle cells and anti-inflammatory actions. These …

Epoxyeicosatrienoic acids (EETs), which are synthesized from arachidonic acid by
cytochrome P450 epoxygenases, function primarily as autocrine and paracrine effectors in …

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the
blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in …

Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites that importantly
contribute to vascular and cardiac physiology. The contribution of EETs to vascular and …

Smooth muscle cell migration occurs during vascular development, in response to vascular
injury, and during atherogenesis. Many proximal signals and signal transduction pathways …

The epoxide hydrolases (EHs) are enzymes present in all living organisms, which transform
epoxide containing lipids by the addition of water. In plants and animals, many of these lipid …

Epoxyeicosatrienoic acids (EETs), which function primarily as autocrine and paracrine
mediators in the cardiovascular and renal systems, are synthesized from arachidonic acid by …

Platelet-derived growth factor BB (PDGF-BB) has been shown to be an extremely potent
negative regulator of smooth muscle cell (SMC) differentiation. Moreover, previous studies …