Enteroendocrine cells are specialized secretory lineage cells in the small and large
intestines that secrete hormones and peptides in response to luminal contents. The various …

Enteroendocrine cells (EECs) are an essential interface between the gut and brain that
communicate signals about nutrients, pain, and even information from our microbiome …

Ca2+-activated BK channels in renal intercalated cells (ICs) mediate luminal flow–induced
K+ secretion (FIKS), but how ICs sense increased flow remains uncertain. We examined …

Of all the organ systems in the body, the gastrointestinal tract is the most complicated in
terms of the numbers of structures involved, each with different functions, and the numbers …

Metal homeostasis is critical to normal neurophysiological activity. Metal ions are involved in
the development, metabolism, redox and neurotransmitter transmission of the central …

ATP and benzoylbenzoyl-ATP (BzATP) increase free cytosolic Ca2+ concentration ([Ca2+] i)
in conjunctival goblet cells (CGCs) resulting in mucin secretion. The purpose of this study …

Background As physical signals, mechanical cues regulate the neural cells in the brain. The
mechanosensitive channels (MSCs) perceive the mechanical cues and transduce them by …

Piezo2 is a mechanically gated ion channel most commonly expressed by specialized
mechanoreceptors, such as the enteroendocrine cells (EECs) of the gastrointestinal …

Serotonin is one of the most potent gastrointestinal, peripheral, and neuronal signaling
molecules, and plays a key role in regulating energy metabolism. Accumulating evidence …

Abdominal pain is the leading cause of morbidity for people living with gastrointestinal
diseases, however pain management remains an unmet clinical challenge. TRPV4 is a …