CD8+ tissue resident memory T cells (TRM cells) are essential for immune defence against
pathogens and malignancies, and the molecular processes that lead to TRM cell formation …

Tissue localization is a critical determinant of T cell immunity. CD8+ T cells are contact-
dependent killers, which requires them to physically be within the tissue of interest to kill …

The simultaneous measurement of multiple modalities represents an exciting frontier for
single-cell genomics and necessitates computational methods that can define cellular states …

Tissue-resident memory T (TRM) cells are non-recirculating cells that exist throughout the
body. Although TRM cells in various organs rely on common transcriptional networks to …

T cell bispecific antibodies (TCBs) are the focus of intense development for cancer
immunotherapy. Recently, peptide-MHC (major histocompatibility complex)-targeted TCBs …

Regionalized immune surveillance relies on the concerted efforts of diverse memory T cell
populations. Of these, tissue-resident memory T (TRM) cells are strategically positioned in …

Tissue-resident memory T (TRM) cells provide long-lasting immune protection. One of the
key events controlling TRM cell development is the local retention of TRM cell precursors …

Skin-resident CD8+ T cells include distinct interferon-γ–producing [tissue-resident memory T
type 1 (TRM1)] and interleukin-17 (IL-17)–producing (TRM17) subsets that differentially …

In metazoans, specific tasks are relegated to dedicated organs that are established early in
development, occupy discrete locations and typically remain fixed in size. The adult immune …

In pancreatic ductal adenocarcinoma (PDAC) patients, we show that response to radiation
therapy (RT) is characterized by increased IL-2Rβ and IL-2Rγ along with decreased IL-2Rα …