T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

One of the most exciting new therapies for cancer involves the use of autologous T cells that
are engineered to recognize and destroy cancerous cells. Patients with previously …

Antigen presentation by major histocompatibility complex class II (MHC-II) molecules is
crucial for eliciting an efficient immune response by CD4+ T cells and maintaining self …

Rheumatoid arthritis (RA) is the most common immune-mediated inflammatory disease
characterized by chronic synovitis that hardly resolves spontaneously. The current treatment …

Both higher-and lower-affinity self-reactive CD4+ T cells are expanded in autoimmunity;
however, their individual contribution to disease remains unclear. We addressed this …

Single-cell molecular tools have been developed at an incredible pace over the last five
years as sequencing costs continue to drop and numerous molecular assays have been …

Type 1 diabetes mellitus (T1DM) is an autoimmune disease that destroys insulin-producing
pancreatic β-cells. Insulin replacement therapy is currently the mainstay of treatment for …

Recently, the remarkable success of chimeric antigen receptor T cell (CAR-T) therapy in
treating certain tumors has led to numerous studies exploring its potential application to treat …

The development of chimeric antigen receptor (CAR)-based therapeutic interventions
represented a breakthrough in cancer treatment. Following the success of the CAR-T-cell …

T cells genetically engineered to recognize and eliminate tumor cells through synthetic
chimeric antigen receptors (CARs) have demonstrated remarkable clinical efficacy against B …