Immune suppression in gliomas

MM Grabowski, EW Sankey, KJ Ryan… - Journal of neuro …, 2021 - Springer
Introduction The overall survival in patients with gliomas has not significantly increased in
the modern era, despite advances such as immunotherapy. This is in part due to their …

The role of selected chemokines and their receptors in the development of gliomas

M Groblewska, A Litman-Zawadzka… - International journal of …, 2020 - mdpi.com
Among heterogeneous primary tumors of the central nervous system (CNS), gliomas are the
most frequent type, with glioblastoma multiforme (GBM) characterized with the worst …

Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression

PP Yee, Y Wei, SY Kim, T Lu, SY Chih… - Nature …, 2020 - nature.com
Tumor necrosis commonly exists and predicts poor prognoses in many cancers. Although it
is thought to result from chronic ischemia, the underlying nature and mechanisms driving the …

Role of inflammatory mediators, macrophages, and neutrophils in glioma maintenance and progression: mechanistic understanding and potential therapeutic …

AS Basheer, F Abas, I Othman, R Naidu - Cancers, 2021 - mdpi.com
Simple Summary The tumor microenvironment is a complex network comprised of
neoplastic and a variety of immune cells, proteins, and inflammatory mediators. Previous …

The flavonoid rutin and its aglycone quercetin modulate the microglia inflammatory profile improving antiglioma activity

AB da Silva, PLC Coelho, M das Neves Oliveira… - Brain, behavior, and …, 2020 - Elsevier
Microglia cells are the immune effector in the Central Nervous System (CNS). However,
studies have showed that they contribute more to glioma progression than to its elimination …

Hallmarks of the tumour microenvironment of gliomas and its interaction with emerging immunotherapy modalities

CA Linares, A Varghese, A Ghose, SD Shinde… - International Journal of …, 2023 - mdpi.com
Gliomas are aggressive, primary central nervous system tumours arising from glial cells.
Glioblastomas are the most malignant. They are known for their poor prognosis or median …

[HTML][HTML] Differential microglia and macrophage profiles in human IDH-mutant and-wild type glioblastoma

CC Poon, PMK Gordon, K Liu, R Yang, S Sarkar… - Oncotarget, 2019 - ncbi.nlm.nih.gov
Microglia and macrophages are the largest component of the inflammatory infiltrate in
glioblastoma (GBM). However, whether there are differences in their representation and …

[HTML][HTML] NLRP3 in human glioma is correlated with increased WHO grade, and regulates cellular proliferation, apoptosis and metastasis via epithelial-mesenchymal …

XF Yin, Q Zhang, ZY Chen… - International …, 2018 - spandidos-publications.com
Glioma is the most prevalent and fatal primary tumor of the central nervous system in adults,
while the development of effective therapeutic strategies in clinical practice remain a …

A New Role for Helicobacter pylori Urease: Contributions to Angiogenesis

D Olivera-Severo, AF Uberti, MS Marques… - Frontiers in …, 2017 - frontiersin.org
Helicobacter pylori is a pathogen involved in gastric diseases such as ulcers and
carcinomas. H. pylori's urease is an important virulence factor produced in large amounts by …

Intense terahertz pulses inhibit Ras signaling and other cancer-associated signaling pathways in human skin tissue models

CM Hough, DN Purschke, C Huang… - Journal of Physics …, 2021 - iopscience.iop.org
Terahertz (THz) radiation has shown unique advantages in biomedical applications for
novel diagnostic technologies due to the high sensitivity to molecular structure and chemical …