Obesity, DNA damage, and development of obesity-related diseases

M Włodarczyk, G Nowicka - International journal of molecular sciences, 2019 - mdpi.com
Obesity has been recognized to increase the risk of such diseases as cardiovascular
diseases, diabetes, and cancer. It indicates that obesity can impact genome stability …

Molecular regulation of DNA damage and repair in female infertility: a systematic review

X Xu, Z Wang, L Lv, C Liu, L Wang, Y Sun… - Reproductive Biology …, 2024 - Springer
DNA damage is a key factor affecting gametogenesis and embryo development. The
integrity and stability of DNA are fundamental to a woman's successful conception …

The influence of oxidative stress on thyroid diseases

J Kochman, K Jakubczyk, P Bargiel, K Janda-Milczarek - Antioxidants, 2021 - mdpi.com
Thyroid diseases, including neoplasms, autoimmune diseases and thyroid dysfunctions, are
becoming a serious social problem with rapidly increasing prevalence. The latter is …

Polycystic ovary syndrome as an independent risk factor for gestational diabetes and hypertensive disorders of pregnancy: a population-based study on 9.1 million …

G Mills, A Badeghiesh, E Suarthana… - Human …, 2020 - academic.oup.com
STUDY QUESTION Does polycystic ovary syndrome (PCOS) confer an independent risk for
the development of gestational diabetes mellitus (GDM), gestational hypertension (GHTN) …

Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in BRCA1 or BRCA2

P Bhardwaj, NM Iyengar, H Zahid, KM Carter… - Science translational …, 2023 - science.org
Obesity, defined as a body mass index (BMI)≥ 30, is an established risk factor for breast
cancer among women in the general population after menopause. Whether elevated BMI is …

Waist-to-height ratio and BMI as predictive markers for insulin resistance in women with PCOS in Kolkata, India

K Bhattacharya, P Sengupta, S Dutta, P Chaudhuri… - Endocrine, 2021 - Springer
Purpose Polycystic ovarian syndrome (PCOS) is most commonly presented with insulin
resistance (IR). Simple anthropometric indices may serve as surrogate markers of these …

[HTML][HTML] Chromosomal damage measured by the cytokinesis block micronucleus cytome assay in diabetes and obesity-A systematic review and meta-analysis

B Franzke, L Schwingshackl, KH Wagner - Mutation Research/Reviews in …, 2020 - Elsevier
The percentage of people affected by overweight, obesity and/or diabetes drastically
increased within the last decades. This development is still ongoing, which puts a large part …

Research progress on the role and mechanism of DNA damage repair in germ cell development

Y Wang, M Su, Y Chen, X Huang, L Ruan… - Frontiers in …, 2023 - frontiersin.org
In the complex and dynamic processes of replication, transcription, and translation of DNA
molecules, a large number of replication errors or damage can occur which lead to …

LRP6 regulates Rab7‐mediated autophagy through the Wnt/β‐catenin pathway to modulate trophoblast cell migration and invasion

L Li, W Peng, Q Zhou, JP Wan… - Journal of cellular …, 2020 - Wiley Online Library
Pre‐eclampsia is a common complication during pregnancy; however, the underlying
mechanisms of the crosstalk between low‐density lipoprotein receptor‐related protein 6 …

A retrospective cohort study of obstetric complications and birth outcomes in women with polycystic ovarian syndrome: Obstetric complications and birth outcomes in …

Q Liu, J Wang, Q Xu, L Kong, J Wang - Journal of Obstetrics and …, 2022 - Taylor & Francis
Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women and a high
risk factor for adverse pregnancy complications. Therefore, we aimed to analyse the …