The Warburg effect and its accompanying metabolic features (anaplerosis, cataplerosis) are
presented in textbooks and reviews as a hallmark (general characteristic): the metabolic …

Lymph nodes (LNs) are strategically positioned outposts of the immune system that
underpin regional immune surveillance. The current model describing LN formation in mice …

Dielectrophoresis (DEP) is an electrokinetic method that allows intrinsic dielectric properties
of suspended cells to be exploited for discrimination and separation. It has emerged as a …

This work describes a 3D, paper-based assay that can isolate sub-populations of cells
based on their invasiveness (ie, distance migrated in a hydrogel) in a gradient of …

The burden of breast cancer continues to increase worldwide as it remains the most
diagnosed tumor in females and the second leading cause of cancer-related deaths. Breast …

The cancer stem cells (CSC) hypothesis represents a pathological extrapolation of the
physiological concept of embryonic and somatic stem cells. In its initial definition, it …

The current paradigm views cancer as arising clonally from a degradation of genetic
information in single cells. A complementary perspective, originating at the dawn of modern …

The vast majority of Parkinson's disease cases are idiopathic. Unclear etiology and
multifactorial nature complicate the comprehension of disease pathogenesis. Identification …

Cells are open, highly ordered systems that are far away from equilibrium. For this reason,
the first function of any cell is to prevent the permanent threat of disintegration that is …

To better understand a role of eIF4E S209 in oncogenic translation, we generated
EIF4ES209A/+ heterozygous knockin (4EKI) HCT 116 human colorectal cancer (CRC) cells …