At specific stages of development, nerve and muscle cells generate spontaneous electrical
activity that is required for normal maturation of intrinsic excitability and synaptic connectivity …

Voltage-gated Na+ channels play important functional roles in the generation of electrical
excitability in most vertebrate and invertebrate species. These channels are members of a …

Membrane excitability in different tissues is due, in large part, to the selective expression of
distinct genes encoding the voltage-dependent sodium channel. Although the predominant …

Ascidians and vertebrates belong to the Phylum Chordata and both have dorsal tubular
central nervous systems. The structure of the ascidian neural tube is extremely simple …

The rapid membrane depolarization associated with action potentials in vertebrate nerve
and muscle is largely a function of Na+ ion diffusion through voltage-gated sodium channels …

Abstract Background Voltage‐gated Na+ channel (VGSC) activity has been implicated in
prostate cancer (PC) metastasis. Although VGSCs can occur as multiple‐subunit …

In many mammalian neurons, dense clusters of ion channels at the axonal initial segment
and nodes of Ranvier underlie action potential generation and rapid conduction. Axonal …

The body plan of the tadpole larva of ascidians, or sea-squirts, is widely presumed to be
close to that of the hypothetical ancestor of all chordate animal groups, including …

Developmental changes in neuronal connectivity and membrane properties underlie the
stage-specific appearance of embryonic behaviors. The behavioral response of embryonic …

With the use of the monoclonal antibody UA301, which specifically recognizes the nervous
system in ascidian larvae, the neuronal connections of the peripheral and central nervous …