RIG-I-like receptors (RLRs) are intracellular pattern recognition receptors that detect viral or
bacterial infection and induce host innate immune responses. The RLRs family comprises …

In 2015, oncolytic virotherapy was approved for clinical use, and in 2017, recombinant
adeno-associated virus (AAV) delivery was also approved. However, systemic …

Oncolytic viruses (OVs) represent a highly promising treatment strategy for a wide range of
cancers, by mediating both the direct killing of tumor cells as well as mobilization of …

Tumors evolve together with the tumor microenvironment (TME) and reshape it towards
immunosuppression. Immunostimulating cytokines can be used to revert this state leading to …

Simple Summary Oncolytic viruses (OV) are engineered viruses designed to replicate
selectively within tumour cells. They hold great promise as novel cancer therapeutics, but …

A promising future for oncology treatment has been brought about by the emergence of a
novel approach utilizing oncolytic viruses in cancer immunotherapy. Oncolytic viruses are …

Gene therapy manipulates or modifies a gene that provides a new cellular function to treat or
correct a pathological condition, such as cancer. The approach of using gene manipulation …

Cancer continues to be one of the leading causes of mortality worldwide despite significant
advancements in cancer treatment. Many difficulties have arisen as a result of the …

Oncolytic viruses (OV) are designed to selectively infect and kill cancer cells, while
simultaneously eliciting antitumour immunity. The mechanism is expected to originate from …

Oncolytic viruses, defined as viruses capable of lysing cancer cells, emerged as a
groundbreaking class of therapeutic entities poised to revolutionize cancer treatment. Their …