Fibrosis is the excessive deposition of a stable extracellular matrix (ECM); fibrotic tissue is
composed principally of highly crosslinked type I collagen and highly contractile …

The diverse members of the CCN family now designated as CCN1 (CYR61), CCN2 (CTGF),
CCN3 (NOV), CCN4 (WISP1), CCN5 (WISP2), CCN6 (WISP3) are a conserved matricellular …

Fibrosis is a common pathological change characterized by the excessive accumulation of
fibrous connective tissue. Once uncontrolled, this pathological progress can lead to …

The aim of the present study was to investigate the underlying mechanism of AS‐IV and
CCN1 in PAH and to evaluate whether the protective effect of AS‐IV against PAH is …

The senescence-associated secretory phenotype (SASP) is a generic term for the secretion
of cytokines, such as pro-inflammatory factors and proteases. It is a crucial feature of …

Background Members of the cellular communication network family (CCN) of matricellular
proteins, like CCN1, have long been implicated in the regulation of cellular processes …

CCN1 (cysteine-rich 61, connective tissue growth factor, and nephroblastoma-1), previously
named CYR61 (cysteine-rich angiogenic inducer 61) belongs to the CCN family of …

CCN/WISP (cellular communication network factors, or Wnt-inducted secreted proteins)
family of proteins consists of six extracellular matrix (ECM)-associated proteins that regulate …

Highlights What are the main findings? Identification of 1888 differentially expressed genes
(DEGs) related to idiopathic pulmonary fibrosis (IPF), including 1105 upregulated and 783 …

Background Melatonin (MEL) is an indole amine molecule primarily produced in the pineal
gland. Melatonin has been shown in numerous studies to have antifibrotic effects on the …