Cell–extracellular matrix mechanotransduction in 3D

A Saraswathibhatla, D Indana… - Nature Reviews Molecular …, 2023 - nature.com
Mechanical properties of extracellular matrices (ECMs) regulate essential cell behaviours,
including differentiation, migration and proliferation, through mechanotransduction. Studies …

Naturally sourced hydrogels: emerging fundamental materials for next-generation healthcare sensing

Z Wang, H Wei, Y Huang, Y Wei, J Chen - Chemical Society Reviews, 2023 - pubs.rsc.org
The flourishing development of flexible healthcare sensing systems is inseparable from the
fundamental materials with application-oriented mechanical and electrical properties …

Soft materials by design: unconventional polymer networks give extreme properties

X Zhao, X Chen, H Yuk, S Lin, X Liu… - Chemical Reviews, 2021 - ACS Publications
Hydrogels are polymer networks infiltrated with water. Many biological hydrogels in animal
bodies such as muscles, heart valves, cartilages, and tendons possess extreme mechanical …

Engineering the multiscale complexity of vascular networks

C O'Connor, E Brady, Y Zheng, E Moore… - Nature Reviews …, 2022 - nature.com
The survival of vertebrate organisms depends on highly regulated delivery of oxygen and
nutrients through vascular networks that pervade nearly all tissues in the body …

Effects of extracellular matrix viscoelasticity on cellular behaviour

O Chaudhuri, J Cooper-White, PA Janmey, DJ Mooney… - Nature, 2020 - nature.com
Substantial research over the past two decades has established that extracellular matrix
(ECM) elasticity, or stiffness, affects fundamental cellular processes, including spreading …

Structurally dynamic hydrogels for biomedical applications: pursuing a fine balance between macroscopic stability and microscopic dynamics

K Zhang, Q Feng, Z Fang, L Gu, L Bian - Chemical Reviews, 2021 - ACS Publications
Owing to their unique chemical and physical properties, hydrogels are attracting increasing
attention in both basic and translational biomedical studies. Although the classical hydrogels …

Chemically modified biopolymers for the formation of biomedical hydrogels

VG Muir, JA Burdick - Chemical reviews, 2020 - ACS Publications
Biopolymers are natural polymers sourced from plants and animals, which include a variety
of polysaccharides and polypeptides. The inclusion of biopolymers into biomedical …

Synthetic alternatives to Matrigel

EA Aisenbrey, WL Murphy - Nature Reviews Materials, 2020 - nature.com
Matrigel, a basement-membrane matrix extracted from Engelbreth–Holm–Swarm mouse
sarcomas, has been used for more than four decades for a myriad of cell-culture …

[HTML][HTML] 3D printing of hydrogels: Rational design strategies and emerging biomedical applications

J Li, C Wu, PK Chu, M Gelinsky - Materials Science and Engineering: R …, 2020 - Elsevier
Abstract 3D printing alias additive manufacturing can transform 3D virtual models created by
computer-aided design (CAD) into physical 3D objects in a layer-by-layer manner …

3D extracellular matrix mimics: fundamental concepts and role of materials chemistry to influence stem cell fate

J Nicolas, S Magli, L Rabbachin, S Sampaolesi… - …, 2020 - ACS Publications
Synthetic 3D extracellular matrices (ECMs) find application in cell studies, regenerative
medicine, and drug discovery. While cells cultured in a monolayer may exhibit unnatural …