The conformational landscapes of peptide/human leucocyte antigen (pHLA) protein
complexes encompassing tumor neoantigens provide a rationale for target selection …

The polymorphic nature and intrinsic instability of class I major histocompatibility complex
(MHC-I) and MHC-like molecules loaded with suboptimal peptides, metabolites, or …

Peptide-centric chimeric antigen receptors (PC-CARs) recognize oncoprotein epitopes
displayed by cell-surface human leukocyte antigens (HLAs) and offer a promising strategy …

Oxidative stress (OS) develops in critically ill patients as a metabolic consequence of the
immunoinflammatory and degenerative processes of the tissues. These induce increased …

Human Tapasin (hTapasin) is the main chaperone of MHC-I molecules, enabling peptide
loading and antigen repertoire optimization across HLA allotypes. However, it is restricted to …

This work focuses on molecules that are encoded by the major histocompatibility complex
(MHC) and that bind self-, foreign-or tumor-derived peptides and display these at the cell …

Adaptive immune responses are triggered by antigenic peptides presented on major
histocompatibility complex class I (MHC I) at the surface of pathogen-infected or cancerous …

The major histocompatibility complex class I (MHC class I)-mediated tumor antigen
processing and presentation (APP) pathway is essential for the recruitment and activation of …

Class I major histocompatibility complex (MHC-I) proteins play a pivotal role in adaptive
immunity by displaying epitopic peptides to CD8+ T cells. The chaperones tapasin and …

Human Tapasin (hTapasin) is the main chaperone of MHC-I molecules, enabling peptide
loading and antigen repertoire optimization across HLA allotypes. However, it is restricted to …