Bioorthogonal chemistry represents a class of high-yielding chemical reactions that proceed
rapidly and selectively in biological environments without side reactions towards …

The emerging inverse electron demand Diels–Alder (IEDDA) reaction stands out from other
bioorthogonal reactions by virtue of its unmatchable kinetics, excellent orthogonality and …

Bioorthogonal reactions have found widespread use in applications ranging from glycan
engineering to in vivo imaging. Researchers have devised numerous reactions that can be …

Bioorthogonal cleavage chemistry has been rapidly emerging as a powerful tool for
manipulation and gain-of-function studies of biomolecules in living systems. While the initial …

Prodrug approaches represent an excellent solution to certain pharmaceutical issues
commonly encountered in the drug discovery and development process. Along this line, the …

Interest in self-immolative chemistry has grown over the past decade with more research
groups harnessing the versatility to control the release of a compound from a larger …

Reactions that occur under physiological conditions find diverse uses in the chemical and
biological sciences. However, the limitations that biological systems place on chemical …

Dissociative bioorthogonal reactions allow for chemically controlling the release of bioactive
agents and reporter probes. Here we describe 3-isocyanopropyl substituents as masking …

The term “in vivo (“in the living”) chemistry” refers to chemical reactions that take place in a
complex living system such as cells, tissue, body liquids, or even in an entire organism. In …

The covalent conjugation of potent cytotoxic agents to either macromolecular carriers or
small molecules represents a well‐known approach to increase the therapeutic index of …