Antibodies to combat viral infections: development strategies and progress

G Pantaleo, B Correia, C Fenwick, VS Joo… - Nature Reviews Drug …, 2022 - nature.com
Monoclonal antibodies (mAbs) are appealing as potential therapeutics and prophylactics for
viral infections owing to characteristics such as their high specificity and their ability to …

Cell-free gene expression

D Garenne, MC Haines, EF Romantseva… - Nature reviews …, 2021 - nature.com
Cell-free gene expression (CFE) emerged as an alternative approach to living cells for
specific applications in protein synthesis and labelling for structural biology and proteomics …

Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection

HM Yassine, JC Boyington, PM McTamney, CJ Wei… - Nature medicine, 2015 - nature.com
The antibody response to influenza is primarily focused on the head region of the
hemagglutinin (HA) glycoprotein, which in turn undergoes antigenic drift, thus necessitating …

Advances in the development of influenza virus vaccines

F Krammer, P Palese - Nature reviews Drug discovery, 2015 - nature.com
Influenza virus infections are a major public health concern and cause significant morbidity
and mortality worldwide. Current influenza virus vaccines are an effective countermeasure …

High-throughput preparation methods of crude extract for robust cell-free protein synthesis

YC Kwon, MC Jewett - Scientific reports, 2015 - nature.com
Crude extract based cell-free protein synthesis (CFPS) has emerged as a powerful
technology platform for high-throughput protein production and genetic part characterization …

Protective antibodies elicited by SARS-CoV-2 spike protein vaccination are boosted in the lung after challenge in nonhuman primates

JR Francica, BJ Flynn, KE Foulds, AT Noe… - Science translational …, 2021 - science.org
Adjuvanted soluble protein vaccines have been used extensively in humans for protection
against various viral infections based on their robust induction of antibody responses. Here …

Current and future influenza vaccines

S Yamayoshi, Y Kawaoka - Nature medicine, 2019 - nature.com
Although antiviral drugs and vaccines have reduced the economic and healthcare burdens
of influenza, influenza epidemics continue to take a toll. Over the past decade, research on …

Applications of synthetic biology in medical and pharmaceutical fields

X Yan, X Liu, C Zhao, GQ Chen - Signal transduction and targeted …, 2023 - nature.com
Synthetic biology aims to design or assemble existing bioparts or bio-components for useful
bioproperties. During the past decades, progresses have been made to build delicate …

A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen

A Impagliazzo, F Milder, H Kuipers, MV Wagner, X Zhu… - Science, 2015 - science.org
The identification of human broadly neutralizing antibodies (bnAbs) targeting the
hemagglutinin (HA) stem revitalized hopes of developing a universal influenza vaccine …

Exploring the potential of cell-free protein synthesis for extending the abilities of biological systems

K Khambhati, G Bhattacharjee, N Gohil… - … in bioengineering and …, 2019 - frontiersin.org
Cell-free protein synthesis (CFPS) system is a simple, rapid, and sensitive tool that is devoid
of membrane-bound barriers, yet contains all the mandatory substrates, biomolecules, and …