Mechanism of action and biology of flow diverters in the treatment of intracranial aneurysms

K Ravindran, AM Casabella, J Cebral, W Brinjikji… - …, 2020 - journals.lww.com
Flow diverters have drastically changed the landscape of intracranial aneurysm treatment
and are now considered first-line therapy for select lesions. Their mechanism of action relies …

Adaptive wireless millirobotic locomotion into distal vasculature

T Wang, H Ugurlu, Y Yan, M Li, M Li, AM Wild… - Nature …, 2022 - nature.com
Microcatheters have enabled diverse minimally invasive endovascular operations and
notable health benefits compared with open surgeries. However, with tortuous routes far …

Injectable hydrogels for vascular embolization and cell delivery: The potential for advances in cerebral aneurysm treatment

S Kim, KW Nowicki, BA Gross, WR Wagner - Biomaterials, 2021 - Elsevier
Cerebral aneurysms are vascular lesions caused by the biomechanical failure of the vessel
wall due to hemodynamic stress and inflammation. Aneurysmal rupture results in …

In-silico trial of intracranial flow diverters replicates and expands insights from conventional clinical trials

A Sarrami-Foroushani, T Lassila, M MacRaild… - Nature …, 2021 - nature.com
The cost of clinical trials is ever-increasing. In-silico trials rely on virtual populations and
interventions simulated using patient-specific models and may offer a solution to lower these …

Poly (2-methoxyethyl acrylate)(PMEA) improves the thromboresistance of FRED flow diverters: a thrombogenic evaluation of flow diverters with human blood under …

K Yoshizawa, H Kobayashi, A Kaneki… - Journal of …, 2023 - jnis.bmj.com
Background Surface modification of flow-diverting stents has been explored to reduce
thrombus-related complications that may arise under clinical use. This study investigated the …

Fully automatic segmentation of 4D MRI for cardiac functional measurements

Y Wang, Y Zhang, W Xuan, E Kao, P Cao… - Medical …, 2019 - Wiley Online Library
Purpose Segmentation of cardiac medical images, an important step in measuring cardiac
function, is usually performed either manually or semiautomatically. Fully automatic …

Computational fluid–structure interactions in the human cerebrovascular system: Part 2—A review of current applications of computational fluid dynamics and …

R Achey, N Thiyagarajah… - … and Science in …, 2022 - asmedigitalcollection.asme.org
The cerebrovascular system is an intricate structure that carries blood to and from the brain.
Though the overall structures remain relatively the same from person to person, variations of …

Hemodynamic investigation of the flow diverter treatment of intracranial aneurysm

MA Boniforti, R Magini, T Orosco Salinas - Fluids, 2023 - mdpi.com
Flow diverter stents (FDS) are increasingly used for the treatment of complex intracranial
aneurysms such as fusiform, giant, or wide-neck aneurysms. The primary goal of these …

First experience of three neurovascular centers with the p64MW-HPC, a low-profile flow diverter designed for proximal cerebral vessels with antithrombotic coating

H Winters, MS Schüngel, C Scherlach, D Mucha… - Frontiers in …, 2021 - frontiersin.org
Background: In the last decade, flow diversion (FD) has been established as hemodynamic
treatment for cerebral aneurysms arising from proximal and distal cerebral arteries …

Fluid dynamics in intracranial aneurysms treated with flow-diverting stents: effect of multiple geometrical parameters

F Chassagne, MC Barbour, MR Levitt… - Journal of Fluid …, 2023 - cambridge.org
Characterizing the haemodynamics in intracranial aneurysms is of high interest as it impacts
aneurysm growth, rupture and treatment, especially with flow-diverting stents (FDS). Flow in …