Tumour-infiltrating lymphocytes (TILs) are considered crucial in anti-tumour immunity.
Accordingly, the presence of TILs contains prognostic and predictive value. In 2011, we …

Microsatellite unstable (MSI) colorectal cancers (CRCs) are due to DNA mismatch repair
(MMR) deficiency and occurs in15% of non-metastatic diseases and 5% in the metastatic …

Immunotherapy has revolutionized colon cancer treatment. Immune checkpoint inhibitors
(ICIs) have shown clinical benefits for colon cancer patients, especially those with high …

We report the results of 24 women, 50%(N= 12) with hormone receptor-positive breast
cancer and 50%(N= 12) with advanced triple-negative breast cancer, treated with …

We present the case of a patient with Lynch syndrome and metastatic colorectal carcinoma
(mCRC). The initial immunohistochemistry (IHC) test for deficient mismatch repair gave a …

Background A significant subset of mismatch repair-deficient (dMMR)/microsatellite
instability-high (MSI-H) gastric adenocarcinomas (GAC) are resistant to immune checkpoint …

Background DNA mismatch repair system deficiency (dMMR) is found in 15% of colorectal
cancers (CRCs). Two methods are used to determine dMMR, immunohistochemistry (IHC) of …

Immunotherapy is a standard of care in many solid tumors but many patients derive limited
benefit from it. There is increasing interest toward tumor infiltrating lymphocytes (TILs) since …

While colorectal cancers (CRC) are paradigmatic tumors invaded by effector memory
lymphocytes, the mechanisms accounting for the relative resistance of MSI negative CRC to …

Background Immune checkpoint inhibitors (ICIs) are highly effective in patients with
microsatellite instability/mismatch repair-deficient (MSI/dMMR) metastatic colorectal cancer …