Multiple recent studies highlight that genetic variants can have strong impacts on a
significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …

We are in a phase of unprecedented progress in identifying genetic loci that cause variation
in traits ranging from growth and fitness in simple organisms to disease in humans …

Genome-wide association studies (GWASs) have become the focus of the statistical analysis
of complex traits in humans, successfully shedding light on several aspects of genetic …

Genome-wide association studies of gene expression traits and other cellular phenotypes
have successfully identified links between genetic variation and biological processes. The …

Recently, many new approaches, study designs, and statistical and analytical methods have
emerged for studying gene-environment interactions (G× Es) in large-scale studies of …

Heritable variation in gene expression forms a crucial bridge between genomic variation
and the biology of many traits. However, most expression quantitative trait loci (eQTLs) …

Background Tobacco smoking is a risk factor for multiple diseases, including cardiovascular
disease and diabetes. Many smoking-associated signals have been detected in the blood …

Different exposures, including diet, physical activity, or external conditions can contribute to
genotype–environment interactions (G× E). Although high-dimensional environmental data …

The ability to predict the agronomic performance of single-crosses with high precision is
essential for selecting superior candidates for hybrid breeding. With recent technological …

Although research effort is being expended into determining the importance of epistasis and
epistatic variance for complex traits, there is considerable controversy about their …