Transposable elements in normal and malignant hematopoiesis

E Lemerle, E Trompouki - Disease Models & Mechanisms, 2023 - journals.biologists.com
Transposable elements (TEs) are dispersed repetitive DNA sequences that can move within
a genome. Even though hundreds of years of evolution have led to the accumulation of …

Repeat Element Activation-Driven Inflammation: Role of NFκB and Implications in Normal Development and Cancer?

B Dumetier, C Sauter, A Hajmirza, B Pernon… - Biomedicines, 2022 - mdpi.com
The human genome is composed of unique DNA sequences that encode proteins and
unique sequence noncoding RNAs that are essential for normal development and cellular …

Systematic single-cell analysis reveals dynamic control of transposable element activity orchestrating the endothelial-to-hematopoietic transition

C Feng, R Tie, S Xin, Y Chen, S Li, Y Chen, X Hu… - BMC biology, 2024 - Springer
Background The endothelial-to-hematopoietic transition (EHT) process during definitive
hematopoiesis is highly conserved in vertebrates. Stage-specific expression of transposable …

Role of ATP-dependent chromatin remodelers in hematopoietic stem and progenitor cell maintenance

Z Tu, Y Zheng - Current opinion in hematology, 2022 - journals.lww.com
The expanding knowledge of ATP-dependent chromatin remodelers in hematopoiesis
illustrates their respective critical roles in HSPC maintenance including the regulation of …

New tools for 'ZEBRA-FISHING'

V Bergo, E Trompouki - Briefings in Functional Genomics, 2021 - academic.oup.com
Zebrafish has been established as a classical model for developmental studies, yet in the
past years, with the explosion of novel technological methods, the use of zebrafish as a …

Transposable elements and the regulatory logic of hematopoietic differentiation

MA Najia - 2023 - dspace.mit.edu
The temporal regulation of gene expression by transcription factors, chromatin modifiers and
cis-regulatory elements is central to establish cellular identity and function. Understanding …