Convalescent plasma therapy in COVID-19: Unravelling the data using the principles of antibody therapy

A Casadevall, MJ Joyner, LA Pirofski… - Expert review of …, 2023 - Taylor & Francis
Introduction When the COVID-19 pandemic struck no specific therapies were available and
many turned to COVID-19 convalescent plasma (CCP), a form of antibody therapy. The …

COVID-19 convalescent plasma for the treatment of immunocompromised patients: a systematic review and meta-analysis

JW Senefeld, M Franchini, C Mengoli… - JAMA Network …, 2023 - jamanetwork.com
Importance Patients who are immunocompromised have increased risk for morbidity and
mortality associated with coronavirus disease 2019 (COVID-19) because they less …

Sulforaphane exhibits antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses in vitro and in mice

AA Ordonez, CK Bullen, AF Villabona-Rueda… - Communications …, 2022 - nature.com
Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the cause of
coronavirus disease 2019 (COVID-19), has incited a global health crisis. Currently, there are …

Severity of SARS-CoV-2 infection in children with inborn errors of immunity (primary immunodeficiencies): a systematic review

S Alhumaid, KM Al Mutared, Z Al Alawi, Z Sabr… - Allergy, Asthma & …, 2023 - Springer
Background Inborn errors of immunity (IEIs) are considered significant challenges for
children with IEIs, their families, and their medical providers. Infections are the most common …

Spike-protein proteolytic antibodies in COVID-19 convalescent plasma contribute to SARS-CoV-2 neutralization

SA McConnell, J Sachithanandham, NJ Mudrak… - Cell Chemical …, 2023 - cell.com
Understanding the mechanisms of antibody-mediated neutralization of SARS-CoV-2 is
critical in combating the COVID-19 pandemic. Based on previous reports of antibody …

Determinants of passive antibody efficacy in SARS-CoV-2 infection

E Stadler, KL Chai, TE Schlub, D Cromer… - MedRxiv, 2022 - medrxiv.org
Background A large number of studies have been carried out involving passive antibody
administration for the treatment and prophylaxis of COVID-19 and have shown variable …

Dosing of Convalescent Plasma and Hyperimmune Anti-SARS-CoV-2 Immunoglobulins: A Phase I/II Dose-Finding Study

S Huygens, T Preijers, FH Swaneveld… - Clinical …, 2024 - Springer
Abstract Background and Objective During the COVID-19 pandemic, trials on convalescent
plasma (ConvP) were performed without preceding dose-finding studies. This study aimed …

The role of convalescent plasma and hyperimmune immunoglobulins in the COVID-19 pandemic, including implications for future preparedness

C So-Osman, T Burnouf, AZ Al-Riyami… - Frontiers in …, 2024 - frontiersin.org
Introduction When Coronavirus Disease-19 (COVID-19) struck the world in December 2019,
initiatives started to investigate the efficacy of convalescent plasma, a readily available …

Use of COVID-19 Convalescent Plasma for Treatment of Symptomatic SARS-CoV-2 Infection at a Children's Hospital: A Contribution to a Still Inadequate Body of …

A Arrieta, AE Galvis, S Osborne, T Morphew, K Imfeld… - Children, 2023 - mdpi.com
Data on COVID-19 convalescent plasma (CCP) safety and efficacy in children and young
adults are limited. This single-center prospective, open-label trial evaluates CCP safety …

[HTML][HTML] SARS-CoV-2 variants from long-term, persistently infected immunocompromised patients have altered syncytia formation, temperature-dependent replication …

C Wouters, J Sachithanandham, E Akin, L Pieterse… - Viruses, 2024 - mdpi.com
SARS-CoV-2 infection of immunocompromised individuals often leads to prolonged
detection of viral RNA and infectious virus in nasal specimens, presumably due to the lack of …