Genetic medicines: treatment strategies for hereditary disorders

TP O'Connor, RG Crystal - Nature Reviews Genetics, 2006 - nature.com
The treatment of the more than 1,800 known monogenic hereditary disorders will depend on
the development of'genetic medicines'—therapies that use the transfer of DNA and/or RNA …

Bioengineering of the uterus

Y Yoshimasa, T Maruyama - Reproductive Sciences, 2021 - Springer
Impairment of uterine structure and function causes infertility, pregnancy loss, and perinatal
complications in humans. Some types of uterine impairments such as Asherman's …

Development of human cloned blastocysts following somatic cell nuclear transfer with adult fibroblasts

AJ French, CA Adams, LS Anderson, JR Kitchen… - Stem …, 2008 - academic.oup.com
Nuclear transfer stem cells hold considerable promise in the field of regenerative medicine
and cell-based drug discovery. In this study, a total of 29 oocytes were obtained from three …

A visible light-cross-linkable, fibrin–gelatin-based bioprinted construct with human cardiomyocytes and fibroblasts

S Anil Kumar, M Alonzo, SC Allen… - ACS biomaterials …, 2019 - ACS Publications
In this study, fibrin was added to a photopolymerizable gelatin-based bioink mixture to
fabricate cardiac cell-laden constructs seeded with human induced pluripotent stem cell …

Development and characterization of furfuryl-gelatin electrospun scaffolds for cardiac tissue engineering

N Nagiah, R El Khoury, MH Othman, J Akimoto, Y Ito… - Acs Omega, 2022 - ACS Publications
In this study, three types of electrospun scaffolds, including furfuryl-gelatin (f-gelatin) alone, f-
gelatin with polycaprolactone (PCL) in a 1: 1 ratio, and coaxial scaffolds with PCL (core) and …

The potential of stem cells in the treatment of knee cartilage defects

WS Khan, DS Johnson, TE Hardingham - The Knee, 2010 - Elsevier
Cartilage is frequently damaged but only shows a limited capacity for repair. There are a
number of treatment strategies currently available for the repair of articular cartilage defects …

Fabrication of poly (ϵ-caprolactone) microfiber scaffolds with varying topography and mechanical properties for stem cell-based tissue engineering applications

J Ko, NK Mohtaram, F Ahmed… - Journal of …, 2014 - Taylor & Francis
Highly porous poly (ϵ-caprolactone) microfiber scaffolds can be fabricated using
electrospinning for tissue engineering applications. Melt electrospinning produces such …

The influence of three-dimensional nanofibrous scaffolds on the osteogenic differentiation of embryonic stem cells

LA Smith, X Liu, J Hu, PX Ma - Biomaterials, 2009 - Elsevier
Embryonic stem cells represent a potentially unlimited cell source for tissue engineering
applications. However, in order to be used for such applications, embryonic stem cells' …

A new approach to the rationale discovery of polymeric biomaterials

J Kohn, WJ Welsh, D Knight - Biomaterials, 2007 - Elsevier
This paper attempts to illustrate both the need for new approaches to biomaterials discovery
as well as the significant promise inherent in the use of combinatorial and computational …

Enhancing osteogenic differentiation of mouse embryonic stem cells by nanofibers

LA Smith, X Liu, J Hu, P Wang, PX Ma - Tissue Engineering Part A, 2009 - liebertpub.com
Controlled differentiation of embryonic stem cells (ESC) is necessary to their use as a cell
source for tissue engineering or regeneration. To date, most studies have concentrated on …