As the sentinels of the immune system, dendritic cells (DCs) play a critical role in initiating
and regulating antigen-specific immune responses. Cross-priming, a process that DCs …

Recent evidence shows that when ischemic stroke (IS) occurs, the BBB would be destructed,
thereby promoting the immune cells to migrate into the brain, suggesting that the immune …

Generating responses to tumor antigens poses a challenge for immunotherapy. This phase
II trial (NCT02129075) tested fms-like tyrosine kinase 3 (Flt3) ligand pre-treatment …

The fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) mutation is associated
with a high relapse rate for patients with acute myeloid leukemia (AML) even after allogeneic …

Coordinated manipulation of independent immune regulatory pathways in the tumor
microenvironment—including blockade of T-cell checkpoint receptors and reversal of …

Immune responses are tightly regulated yet highly variable between individuals. To
investigate human population variation of trained immunity, we immunized healthy …

Cancer immunotherapy harnesses the ability of the immune system to recognize and
eliminate cancer. The potent ability of dendritic cells (DCs) to initiate and regulate adaptive …

Although plasmacytoid dendritic cells (pDCs) have been shown to play a critical role in
generating viral immunity and promoting tolerance to suppress antitumor immunity, whether …

The term atherosclerosis refers to the condition of deposition of lipids and other substances
in and on the artery walls, called as plaque that restricts the normal blood flow. The plaque …

Recent studies have identified molecular events characteristic of immunogenic cell death
(ICD), including surface exposure of calreticulin (CRT), the heat shock proteins HSP70 and …