Mechanisms and disease consequences of nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide. Its
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …
Circadian rhythm as a therapeutic target
The circadian clock evolved in diverse organisms to integrate external environmental
changes and internal physiology. The clock endows the host with temporal precision and …
changes and internal physiology. The clock endows the host with temporal precision and …
Circadian rhythms and the gut microbiota: from the metabolic syndrome to cancer
The metabolic syndrome is prevalent in developed nations and accounts for the largest
burden of non-communicable diseases worldwide. The metabolic syndrome has direct …
burden of non-communicable diseases worldwide. The metabolic syndrome has direct …
Clocks, cancer, and chronochemotherapy
A Sancar, RN Van Gelder - Science, 2021 - science.org
BACKGROUND The core of the mammalian circadian clock mechanism is a time-delayed
transcription-translation feedback loop (TTFL), which influences the transcription and …
transcription-translation feedback loop (TTFL), which influences the transcription and …
Interplay between circadian clock and cancer: new frontiers for cancer treatment
Circadian clocks constitute the evolutionary molecular machinery that dictates the temporal
regulation of physiology to maintain homeostasis. Disruption of the circadian rhythm plays a …
regulation of physiology to maintain homeostasis. Disruption of the circadian rhythm plays a …
Cause, pathogenesis, and treatment of nonalcoholic steatohepatitis
AM Diehl, C Day - New England Journal of Medicine, 2017 - Mass Medical Soc
Nonalcoholic steatohepatitis is a major cause of cirrhosis and liver cancer. It is associated
with visceral adiposity and the metabolic syndrome and is nearly as common as type 2 …
with visceral adiposity and the metabolic syndrome and is nearly as common as type 2 …
Genomics of circadian rhythms in health and disease
F Rijo-Ferreira, JS Takahashi - Genome medicine, 2019 - Springer
Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral
processes. The central circadian clock exerts control over myriad aspects of mammalian …
processes. The central circadian clock exerts control over myriad aspects of mammalian …
Circadian regulator BMAL1:: CLOCK promotes cell proliferation in hepatocellular carcinoma by controlling apoptosis and cell cycle
Hepatocellular carcinoma (HCC) remains a global health challenge whose incidence is
growing worldwide. Previous evidence strongly supported the notion that the circadian clock …
growing worldwide. Previous evidence strongly supported the notion that the circadian clock …
Risk factors and prevention of hepatocellular carcinoma in the era of precision medicine
Patients who develop chronic fibrotic liver disease, caused by viral or metabolic aetiologies,
are at a high risk of developing hepatocellular carcinoma (HCC). Even after complete HCC …
are at a high risk of developing hepatocellular carcinoma (HCC). Even after complete HCC …
RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner
X Guo, K Li, W Jiang, Y Hu, W Xiao, Y Huang, Y Feng… - Molecular cancer, 2020 - Springer
Abstract Background N6-methyladenosine (m6A) is the most abundant reversible
methylation modification of eukaryotic mRNA, and it plays vital roles in tumourigenesis. This …
methylation modification of eukaryotic mRNA, and it plays vital roles in tumourigenesis. This …